摘要
病毒感染驱动的代谢改变是病毒致癌的重要机制,病毒由于缺乏完整的酶系统,必须依赖宿主细胞的代谢体系.在长期进化过程中,致瘤病毒通过其自身编码的产物改变宿主细胞的代谢模式,以有利于病毒生存,同时满足肿瘤细胞对代谢的需求,发挥多重生物学效应.为此,在病毒感染相关肿瘤中探讨病毒如何影响宿主细胞代谢通路,阐明其代谢重塑的特点与机制,揭示这种代谢改变的临床意义将从一个新的角度丰富人们对病毒与癌变的认识,为发展新的靶向策略提供启示.
Metabolic alterations driven by viral infection are an important mechanism for viral carcinogenesis.Due to the lack of a complete enzyme system,viruses must rely on the metabolic machinery of host cells.In the long process of evolution,oncogenic viruses change the metabolic pattern of host cells through their own encoded products,which is conducive to the survival of the virus,while meeting the metabolic needs of tumor cells and playing multiple biological effects.Therefore,exploring how viruses affect host cell metabolic pathways in viral infection-related tumors,elucidating the characteristics and mechanisms of metabolic remodeling,and revealing the clinical significance of such metabolic changes will enrich our understanding of viruses and carcinogenesis from a novel perspective,and provide enlightenment for the development of new targeting strategies.
作者
曹亚
张哲
CAO Ya;ZHANG Zhe(Key Laboratory of Carcinogenesis and Cancer Invasion,Chinese Ministry of Education,Cancer Research Institute of Central South University,Changsha 410078,China;Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor,Ministry of Education,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2024年第12期2288-2297,共10页
Scientia Sinica(Vitae)
基金
国家自然科学基金(批准号:81430064,81672705,81874172,82073030,82103019,82303258,82303137,U22A20322)资助。
关键词
EB病毒
致癌
宿主代谢
重塑
Epstein-barr virus
carcinogenesis
host metabolism
remodeling
