摘要
EB病毒属于人类疱疹病毒γ亚科,感染全球超过90%人口.EB病毒感染每年导致数百万非肿瘤和超过20万恶性肿瘤新发病例.人类B细胞和上皮细胞是EB病毒的主要宿主细胞.EB病毒入侵宿主细胞机制非常复杂,需要多个病毒包膜糖蛋白与不同宿主因子协同作用决定其宿主嗜性.近年来,科学家们对EB病毒感染机制的研究不断深入,为EB病毒相关疾病的精准防治提供了新思路.本文将系统介绍EB病毒感染机制研究的现状和未来展望方向,旨在深入理解EB病毒与宿主互作机理及干预靶点.
Epstein-barr virus(EBV)belongs to the human herpesvirus gamma subfamily and infects more than 90%of the world’s population.EBV infection causes millions of new cases of noncancer and more than 200000 new cases of cancer each year.Human B cells and epithelial cells are the main host cells of EBV.The invasion mechanism of EBV into host cells is very complex,which requires multiple viral envelope glycoproteins to cooperate with different host factors to determine its host tropism.In recent years,scientists have deepened their research on the mechanism of EBV infection,which provides new ideas for the precise prevention and treatment of EBV-related diseases.This review will systematically introduce the current status and prospects of the research on the mechanism of EBV infection.
作者
张华
张婷
庞德
陈颖柔
ZHANG Hua;ZHANG Ting;PANG De;CHEN Ying(Rou Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases,School of Medicine,Shenzhen Campus of Sun Yat-sen University,Sun Yat-sen University,Shenzhen 518107,China)
出处
《中国科学:生命科学》
CSCD
北大核心
2024年第12期2263-2273,共11页
Scientia Sinica(Vitae)
基金
国家自然科学基金(批准号:82372246)
深圳市基础研究项目(批准号:JCYJ20230807111219040)资助。
关键词
EB病毒
感染
受体
恶性肿瘤
B细胞
上皮细胞
Epstein-barr virus
infection
receptors
malignant neoplasms
B cells
epithelial cells
