摘要
年龄相关性黄斑变性(AMD)是一种由多种因素引起的退行性疾病,是导致严重视力丧失的主要原因之一。孟德尔随机化(MR)使用遗传变异作为工具变量来检测和量化暴露与结局的因果关系,克服了观察性研究和随机对照试验的局限性。近年来,MR在AMD的病因推断研究中得到了广泛应用。本文对MR进行概述,总结了与AMD相关的MR研究,重点探讨不同风险因素与AMD发病之间的因果关系,为AMD的病因学研究和预防策略制定提供依据。
Age-related macular degeneration(AMD)is a degenerative disease caused by multiple factors,and it is one of the leading causes of severe vision loss.Mendelian randomization(MR)uses genetic variation as an instrumental variable to detect and quantify the causal relationship between exposure and outcomes,overcoming the limitations of observational studies and randomized controlled trials.In recent years,MR has been widely used in the etiological inference of AMD.In this paper,MR studies related to AMD are summarized,focusing on the causal relationship between different risk factors and the onset of AMD,so as to provide a basis for the etiological research and prevention strategy development of AMD.
作者
张文峰
宋琼涛
刘春梦
常璐
张富文
ZHANG Wenfeng;SONG Qiongtao;LIU Chunmeng;CHANG Lu;ZHANG Fuwen(Chengdu University of TCM,Chengdu 610075,Sichuan Province,China;Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection,Chengdu 610075,Sichuan Province,China;Ineye Hospital of Chengdu University of TCM,Chengdu 610084,Sichuan Province,China)
出处
《眼科新进展》
CAS
北大核心
2025年第1期71-76,共6页
Recent Advances in Ophthalmology
基金
国家自然科学基金青年科学基金项目(编号:82004428)
四川省自然科学基金面上项目(编号:2023NSFSC0690)。
关键词
年龄相关性黄斑变性
孟德尔随机化
因果推断
age-related macular degeneration
Mendelian randomization
causal inference
