摘要
年龄相关性黄斑变性(AMD)是一种导致严重视力丧失的眼病。该病症的关键病理特征之一是视网膜的神经炎症反应。NLRP3炎症小体在调节这种神经炎症中扮演着至关重要的角色。研究表明,在AMD的发展过程中,NLRP3炎症小体的激活与线粒体的损伤、活性氧的产生及线粒体DNA的异常释放紧密相关。因此,针对NLRP3炎症小体的抑制剂可能成为一种对AMD治疗极具潜力的新方法。本文对线粒体损伤与NLRP3炎症小体信号途径在AMD发病机制中的作用进行了全面综述,展望了这一领域的研究进展。
Age-related macular degeneration(AMD)is a critical ophthalmic condition characterized by substantial visual impairment.Retinal neuroinflammation is one of the fundamental pathophysiological features of AMD.The NOD-like receptor protein 3(NLRP3)inflammasome plays a crucial role in regulating neuroinflammation.It has been demonstrated that the activation of NLRP3 inflammasome is closely correlated with mitochondrial dysfunction,the increased production of reactive oxygen species(ROS),and the anomalous expulsion of mitochondrial DNA in the progression of AMD.Therefore,inhibitors targeting the NLRP3 inflammasome may become a new approach with great potential for AMD treatment.This article rigorously examines the role of mitochondrial impairment and NLRP3 inflammasome signaling in the pathogenesis of AMD,highlighting current research advancements and prospective trajectories in this evolving field.
作者
邹悦
李云琴
谭欣
蒋俊良
ZOU Yue;LI Yunqin;TAN Xin;JIANG Junliang(Affiliated Hospital of Yunnan University(Second People’s Hospital of Yunnan Province,Yunnan Eye Hospital),Kunming 650021,Yunnan Province,China)
出处
《眼科新进展》
CAS
北大核心
2025年第1期60-65,共6页
Recent Advances in Ophthalmology
基金
国家自然科学基金(编号:81371042)
云南省科技厅-昆明医科大学联合专项(编号:202301AY070001-086)
云南省中青年学术和技术带头人后备人才项目(编号:202305AC160073)
云南省教育厅科学研究基金项目(编号:2024Y927)。
关键词
年龄相关性黄斑变性
炎症小体
线粒体
神经炎症
age-related macular degeneration
inflammasome
mitochondrion
neuroinflammation
