摘要
目的:探讨硫辛酸联合甲巯咪唑治疗甲状腺功能亢进症的效果。方法:选取2022年5月—2024年5月秦皇岛市海港医院内分泌科收治的76例甲状腺功能亢进症患者作为研究对象,采用随机数表法分为试验组和常规组,各38例。常规组应用甲巯咪唑治疗,试验组在常规组基础上应用硫辛酸治疗。对比两组疗效,甲状腺激素水平,血糖、血脂指标水平,不良反应发生情况。结果:试验组治疗总有效率高于常规组(P=0.001);治疗后,两组促甲状腺激素水平升高,游离三碘甲腺原氨酸、游离甲状腺素、总三碘甲腺原氨酸、总甲状腺素水平降低,试验组优于常规组(P<0.05);治疗后,两组空腹血糖、餐后2 h血糖、低密度脂蛋白胆固醇水平降低,高密度脂蛋白胆固醇水平升高,试验组优于常规组(P<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论:硫辛酸联合甲巯咪唑治疗甲状腺功能亢进症的效果较好,有利于调节甲状腺功能激素、血糖、血脂水平,安全性良好。
Objective:To investigate the effect of lipoic acid combined with methimazole in the treatment of hyperthyroidism.Methods:A total of seventy-six hyperthyroidism patients admitted to the endocrinology department of Qinhuangdao Harbor Hospital from May 2022 to May 2024 were selected as the study objects,and were divided into experimental group and conventional group by random number table method,with thirty-eight cases in each group.The conventional group was treated with methophobidazole,and the experimental group was treated with lipoic acid based on the conventional group.The efficacy,thyroid hormone levels,blood glucose and lipid levels and the occurrence of adverse reactions were compared between the two groups.Results:The total effective rate of experimental group was higher than that of conventional group(P=0.001);after treatment,the levels of thyrotropin increased and the levels of free triiodothyronine,free thyroxine,total triiodothyronine and total thyroxine decreased in two groups,and the experimental group was better than the conventional group(P<0.05);after treatment,fasting blood glucose,2 h postprandial blood glucose and low density lipoprotein cholesterol levels were decreased,and high density lipoprotein cholesterol levels were increased in both groups,and the experimental group was better than the conventional group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Lipoic acid combined with methimazole has a good effect on the treatment of hyperthyroidism,which is beneficial to regulate the levels of thyroid hormone,blood glucose and lipid,and has good safety.
作者
门晓彦
Men Xiaoyan(Department of Endocrinology,Qinhuangdao Harbor Hospital,Qinhuangdao 066000,Hebei Province,China)
出处
《中外医药研究》
2024年第31期75-77,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
