摘要
目的探讨骨代谢生化指标与绝经后骨质疏松性腰椎骨折的关系.方法选取80例绝经后骨质疏松症患者作为研究对象,将发生腰椎骨折的37例患者纳入观察组,将未发生腰椎骨折的43例患者纳入对照组,比较2组的骨密度、骨代谢生化指标,分析骨代谢生化指标与绝经后骨质疏松性腰椎骨折的关系.结果2组腰椎骨密度、髋部骨密度、血钙(Ca2+)、骨钙素N端中分子(N-MID)比较,差异无统计学意义(P>0.05);观察组25-羟基维生素D[25-(OH)D]水平低于对照组,Ⅰ型胶原羧基端肽β特殊序列(β-CTX)、Ⅰ型前胶原氨基端前肽(PINP)、骨碱性磷酸酶(BALP)水平高于对照组,差异有统计学意义(P<0.05);绝经后骨质疏松性腰椎骨折与BALP、PINP呈正相关(P<0.05),与25-(OH)D呈负相关(P<0.05),与β-cTX无相关性(P>0.05).结论BALP、PINP、25-(OH)D与绝经后骨质疏松性腰椎骨折的发生关联密切,其中BALP、PINP是其危险因素,25-(OH)D是其保护因素.
Objective To investigate the relationship between bone metabolism biochemical indexes and lumbar vertebrae fractures caused by postmenopausal osteoporosis.Methods A total of80 patients with postmenopausal osteoporosis in our hospital were included in the study,among whom37 patients with lumbar fractures were selected as observation group,43 without were selected as control group.Bone mineral density and bone metabolism biochemical index were compared,and relation between bone metabolic biochemical indicators and osteoporotic lumbar vertebrae fracture after menopause was analyzed.Results There were no significant differences in bone density of lumbar spine and hip,serum calcium(Ca2+)and N-terminal-mid fragment of osteocalcin(N-MID)between the two groups(P>0.05).The 25-hydroxyvitamin D[25-(OH)D]of the observation group was lower,andβ-isomerized C-terminal telopeptide of type I collagen(β-CTX),N-terminal propeptide of typeⅠcollagen(PINP),bone alkaline phosphatase(BALP)were higher than those in the control group(P<0.05).Osteoporotic lumbar vertebrae fracture after menopause showed a positive correlation with BALP and PINP(P<0.05),a negative correlation with 25-(OH)D(P<0.05),and no correlation withβ-CTX(P>0.05).Conclusion BALP,PINP and 25-(OH)D are closely related to postmenopausal osteoporotic lumbar vertebrae fractures,with BALP and PINP as risk factors and25-(OH)D as protective factors.
作者
姚颖
刘玮
YAO Ying;LIU Wei(Department of Laboratory Medicine,Xi’an Red Cross Hospital Affiliated to Xi’an Jiaotong University,Xi'an,Shaanxi,710054;Department of Blood Transfusion,Xi’an Red Cross Hospital Affiliated to Xi’an Jiaotong University,Xi'an,Shaanxi,710054)
出处
《实用临床医药杂志》
CAS
2020年第7期112-115,共4页
Journal of Clinical Medicine in Practice
关键词
骨代谢
骨质疏松
绝经
腰椎骨折
bone metabolism
osteoporosis
menopause
lumbar fracture
