摘要
目的借助公共数据库分析SLC7A3在乳腺癌中的差异表达及预后价值,并结合SLC7A3的互作蛋白网络、协同表达对SLC7A3进行功能分析。方法运用Oncomine、GEPIA、Ualcan数据库分析SLC7A3在乳腺癌中的表达,在GEPIA和Kaplan-Meier Plotter数据库中进行生存分析,通过TISIDB、String、GeneMANIA和Oncomine数据库进行协同分析,并借助Metascape对功能富集分析注释。结果SLC7A3在乳腺癌中表达水平低于正常乳腺组织,SLC7A3低表达的乳腺癌患者无远处转移生存期、无复发生存期和总生存期显著缩短,预后不佳。SLC7A3在luminal型乳腺癌和三阴性乳腺癌中的表达水平高于HER2过表达型乳腺癌,功能分析显示SLC7A3与细胞分裂、黏附等相关,调节IGF及非经典Wnt通路,抑制细胞生长。结论SLC7A3在乳腺癌中低表达,具有提示预后的价值。
Objective To explore the differential expression and prognostic value of SLC7A3 in breast cancer and analyze the function of SLC7A3 with protein-protein interaction network and co-expression genes.Methods SLC7A3 expression in breast cancer was determined with Oncomine,GEPIA and Ualcan databases.Survival analysis was performed with GEPIA and Kaplan-Meier Plotter databases.Co-expression and protein-protein interaction networks were obtained with TISIDB,String,GeneMANIA and Oncomine databases.Functional analysis was performed with help of Metascape.Results SLC7A3 was significantly down-regulated in breast cancer compared with normal breast and its low expression was related to unfavorable prognosisincluding significantly shorterdistant metastasis free survival,recurrence free survival and overall survival.SLC7A3 expression was higher in Luminal subtype and triple negative breast cancer compared to HER2 overexpression breast cancer.Functional analysis showed that SLC7A3 was related to cell division and adhesion,regulating IGF and non-canonical Wnt signaling pathway,andinhibiting cell proliferation.Conclusion SLC7A3 is down regulated in breast cancer and serves as a prognostic factor.
作者
王羽纶
刘彩刚
WANG Yu-lun;LIU Cai-gang(Department of Breast Surgery of Seventh General Surgery,Shengjing Hospital of China Medical University,Shenyang 110022,China)
出处
《解剖科学进展》
CAS
2024年第5期471-474,共4页
Progress of Anatomical Sciences
基金
国家自然科学基金(81872159)。
