摘要
以脂肪酸(FA)对黄花蒿叶中青蒿素的超声辅助提取为外循环,以聚醚胺(D230)的CO_(2)开关为内循环,构建一种基于脂肪酸的双循环CO_(2)开关溶剂体系。采用单因素实验和正交实验考察了液固比(mL∶g,即每克黄花蒿叶粉末加入脂肪酸体积,下同)、超声时间、提取温度和提取时间对青蒿素提取量的影响。采用SEM、FTIR和1HNMR对其进行了表征,探究了基于脂肪酸的双循环CO_(2)开关溶剂体系提取分离青蒿素的机理。在以正庚酸(C_(7)-FA)为提取溶剂、液固比(mL∶g)为20∶1、超声时间1.00h、提取温度50℃、提取时间2.5h的最佳条件下,青蒿素提取量为4.37 mg/g。C_(7)-FA与D230/水溶液组成了具有CO_(2)开关能力的双循环溶剂体系,可快速分离青蒿素并实现溶剂的回收和循环利用,第4次使用时青蒿素提取量为新鲜溶剂提取量的78%。范德华力和氢键是提取中的主要分子间作用力。
A dual-circulation CO_(2)-switchable solvent system based on fatty acids was constructed by ultrasound-assisted extraction of artemisinin from Artemisia annua leaves using fatty acids as external cycle,and CO_(2)switching of polyether amine(D230)as internal cycle.The effects of liquid-solid ratio(m L∶g,that is,the volume of fatty acids added per gram of Artemisia annua leaf powder,the same below),ultrasound time,extraction temperature and extraction time on the amount of artemisinin extracted were investigated by single-factor experiments and orthogonal experiments.The artemisinin extracted was characterized by SEM,FTIR and^(1)HNMR,and its extraction and separation mechanism using a double-circulation CO_(2)-switching solvent system based on fatty acids was further analyzed.Under the optimal extraction conditions of n-heptanoic acid(C_(7)-FA)as extraction solvent,liquid-solid ratio(m L∶g)20∶1,ultrasonication time 1.00 h,extraction temperature 50℃,and extraction time 2.5 h,the amount of artemisinin extracted was 4.37 mg/g.C_(7)-FA and D230/water solution formed a double-circulation solvent system with CO_(2)-switchable ability,which could rapidly separate artemisinin and achieve solvent recovery and recycling,and the amount of artemisinin extracted in the fourth cycle was 78%of that extracted in fresh solvent.Van der Waals force and hydrogen bonds were the main intermolecular forces in extraction.
作者
陈川
田云
郭龙燕
王娜
鲁红升
CHEN Chuan;TIAN Yun;GUO Longyan;WANG Na;LU Hongsheng(College of Chemistry and Chemical Engineering,Southwest Petroleum University,Chengdu 610500,Sichuan,China)
出处
《精细化工》
EI
CAS
CSCD
北大核心
2024年第12期2702-2709,2753,共9页
Fine Chemicals
基金
四川省自然科学基金面上项目(2022NSFSC0203)。
关键词
脂肪酸
双循环
CO_(2)开关溶剂
提取
青蒿素
分离技术
fatty acids
dual-circulation
CO_(2)-switchable solvents
extraction
artemisinin
separation technology
