摘要
实验选取健康SD大鼠作为研究对象,研究了丹皮酚对大鼠空肠运动功能的影响.大鼠麻醉后取出大约2 cm长的空肠组织,采用Krebs液进行离体组织灌流保持其生理活性.在灌流液中加入不同剂量的丹皮酚溶液,观察丹皮酚对肠段自发收缩运动的作用,加入乙酰胆碱诱发空肠高张力收缩,而后再加丹皮酚,观察丹皮酚对乙酰胆碱诱发性收缩的作用.研究结果显示丹皮酚对大鼠空肠的自发性收缩与诱发性收缩皆有舒张作用.
A Healthy SD rat is selected as the research object to study the effect of paeonol on the jejunal motility function.Approximately 2cm of jejunal tissue is extracted from the anesthetized rat and perfused with Krebs solution to maintain its physiological activity.In the perfusion fluid,different doses of paeonol solution are added,and the effect of paeonol on spontaneous contraction of intestinal segments is observed.Then,acetylcholine is added into the perfusion fluid to induce high tension contraction of the jejunum.After that,the experiment adds paeonol and observes its effect on acetylcholine induced contractions.The results show that paeonol has a relaxing effect on both spontaneous and induced contractions of the rat jejunum.
作者
路雯
刘维豪
胡晨晨
翟珂晗
张贵生
LU Wen;LIU Wei-hao;HU Chen-chen;ZHAI Ke-han;ZHANG Gui-sheng(School of Agricultural and Biological Engineering,Heze University,Heze Shandong 274015,China;Shandong Dashu Dafu Food Co.,LTD.,Heze Shandong 274015,China)
出处
《菏泽学院学报》
2024年第5期123-128,共6页
Journal of Heze University
基金
国家自然科学基金(82200477)
菏泽学院博士科研基金项目(XY22BS21)。
关键词
丹皮酚
空肠
舒张作用
paeonol
jejunum
diastolic effect
