摘要
威灵仙作为常用中药材,分布于中国云南南部、贵州、四川、陕西南部、广西等地区。通过收集威灵仙在古代本草、医籍、史书中相关记载,并结合近现代研究资料,对威灵仙的名称、基原、功效进行系统的本草考证,同时对化学成分及药理作用进行分析。经考证发现,威灵仙别名较多,包括铁扫帚、铁脚威灵仙、山辣椒秧、百条根、山蓼等。威灵仙的性味记载多为味苦、辛、咸等,有祛风除湿、通络止痛等功效,功效主治古今差异不大。威灵仙主要包括黄酮类、皂苷类、白头翁素与原白头翁素、木脂素类等化学成分,还具有抗炎镇痛、抗肿瘤、抗氧化、保肝、利胆等药理作用。文章旨在为中药材威灵仙的研究拓宽思路,并为威灵仙在新药研发及其临床的广泛应用提供理论基础。
As a commonly used Chinese medicinal herb,Weilingxian(Clematidis Radix Et Rhizoma)is distributed in southern Yunnan,Guizhou,Sichuan,southern Shaanxi,Guangxi and other regions of China.By collecting relevant records of Weilingxian(Clematidis Radix Et Rhizoma)in ancient Chinese herbal medicine,medical books,and historical books,and combining modern and contemporary research materials,a systematic textual research is conducted on the name,origin,and efficacy of Weilingxian(Clematidis Radix Et Rhizoma),while analyzing its chemical composition and pharmacological effects.After investigation,it was found that there are many aliases for Weilingxian(Clematidis Radix Et Rhizoma),including Iron Broom,Iron Foot Weilingxian,Mountain Pepper Seedling,Baitiao Root,Mountain Polygonum,etc.The recorded nature and taste of Weilingxian(Clematidis Radix Et Rhizoma)are mostly bitter,spicy,salty,etc.It has the effects of dispelling wind,removing dampness,unblocking collaterals,and relieving pain,with little difference in efficacy between ancient and modern times.Weilingxian(Clematidis Radix Et Rhizoma)mainly includes chemical components such as flavonoids,saponins,berberine,protoberberine,lignans,etc.It also has pharmacological effects such as anti-inflammatory and analgesic,anti-tumor,antioxidant,hepatoprotective,and bile promoting.This article aims to broaden the research ideas for the traditional Chinese medicine Weilingxian(Clematidis Radix Et Rhizoma)and provide a theoretical basis for the widespread application of Weilingxian(Clematidis Radix Et Rhizoma)in new drug development and clinical practice.
作者
孙恺婧
穆慧
孙莹
刘馨泽
金鑫
陈长宝
万茜淋
SUN Kaijing;MU Hui;SUN Ying;LIU Xinze;JIN Xin;CHEN Changbao;WAN Xilin(Jilin Ginseng Academy,Changchun University of Chinese Medicine,Changchun 130117,Jilin,China;The Second Hospital of Dalian Medical University,Dalian 116027,Liaoning,China;Key Laboratory of Molecular Epigenetics,Northeast Normal University,Ministry of Education,Changchun 130021,Jilin,China)
出处
《辽宁中医药大学学报》
CAS
2024年第12期179-184,共6页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金(32101028)
吉林省科技发展计划项目(20230508166RC)
吉林省教育厅科学技术研究项目(JJKH20241091KJ,JJKH20231312KJ)。
关键词
威灵仙
本草考证
化学成分
药理作用
Weilingxian(Clematidis Radix Et Rhizoma)
herbal research
chemical composition
pharmacological action
