摘要
目的基于《伤寒杂病论》中《伤寒论》和《金匮要略》两部中医经典古籍,统计其中“对药”方剂的数据,分析相关“对药”方剂用药规律和病证规律,以期为开展“对药”方剂相关研究提供参考。方法查阅《伤寒论》《金匮要略》中正方258首,附方23首,以及“杂疗”“饮食”“禁忌”3篇中的57首,根据纳排标准筛选出“对药”方剂,梳理其主治病证、单味药出现频次、药物气味归经、药物功能类别等信息,对条文中相关中医临床术语和中药名称进行规范化,建Excel数据库,运用SPSS Modeler 18.0软件对条文涉及病证进行关联规则分析、复杂网络分析,运用SPSS 26.0对病证、药物频次进行统计分析。结果共筛选出41首“对药”方剂,根据排纳标准纳入37首。涉及不重复条文56条,其中《伤寒论》中纳入17条,《金匮要略》纳入39条,共使用不重复中药47味,使用频次最高的药物有4味,分别是百合、半夏、干姜、生甘草。药物性味归经、功效分析显示,药性以寒性为主,药味主要为甘味,归经以入肺经者最多,功效以补虚类药物最常见。在条文症状统计分析中,筛选出症状88种,出现频次最高的症状是心烦。在症状的关联规则、复杂网络分析中显示,百合病涉及的口苦、小便赤、默默、不得卧等症状,为《伤寒杂病论》中“对药”方剂的核心症状组合,栀子豉汤等证中的心烦、身热症状组合次之。结论通过对《伤寒杂病论》中“对药”方剂的条文、方药、病证进行分析和统计,发现其中具有一定的规律性,以期为“对药”方剂更广泛的临床应用、药效学机制的深入研究及基于古方的中药新药开发提供一定参考。
Objective To count the data of the prescriptions of“couplet medicines”and analyze the patterns of medication and diseases of related“couplet medicines”prescriptions using the two classic ancient Chinese medicine books Treatise on Febrile Diseases and Synopsis of the Golden Chamber in Treatise on Febrile and Miscellaneous Diseases,in order to provide some reference for carrying out relevant research on“couplet medicines”prescriptions.Methods 258 prescriptions,23 attaching prescriptions,and 57 prescriptions on“miscellaneous therapy”“diet”and“contraindications”in Treatise on Febrile Diseases and Synopsis of the Golden Chamber were checked.According to the inclusion and exclusion criteria,the“couplet medicines”prescriptions were screened out,the information such as the main symptoms,and the frequency of single drug occurrence,the flavor of the drug,the meridian tropism,and the functional category of the drug were sorted out,and the relevant TCM clinical terms and TCM names in the clauses were standardized,and the corresponding Excel database was established.SPSS Modeler 18.0 software was used for association rule analysis and complex network analysis of the clauses involving diseases,and SPSS 26.0 was used for statistical analysis of diseases and drug frequencies.Results Totally 41 prescriptions were selected,and 37 were finally included according to the criteria.Among them,56 non-repetitive clauses were involved,of which 17 clauses were included in the Treatise on Febrile Diseases and 39 clauses were included in the Synopsis of the Golden Chamber,and 47 non-repetitive herbal medicines were used,with the four most frequently used medicines being Baihe(Lilii Bulbus),Banxia(Pinelliae Rhizoma),Ganjiang(Zingiberis Rhizoma),Gancao(Glycyrrhizae Radix Et Rhizoma).According to the analysis of the four properties,five tastes,meridian tropism and efficacy of herbal medicines,the herbs were primarily cold in property,sweet in taste,the meridian tropism was primarily bladder meridian,and the main herbs of efficacy were primarily tonic medicine.88 symptoms were screened in the statistical analysis of article symptoms,and the symptom with the highest frequency of occurrence was upset.The analysis of association rules and complex networks of symptoms revealed that symptoms such as bitter taste,brown urine,silence,and inability to lie down associated with Baihe disease were the core symptom combinations in pairs of prescriptions in the Treatise on Typhoid Miscellaneous Diseases,followed by symptom combinations of heart distress and heat in the body in evidence such as Zhizichi Decoction(栀子豉汤).Conclusion Through the analysis and statistics of the clauses,prescriptions and diseases of the“couplet medicines”prescriptions in Treatise on Febrile Diseases and Synopsis of the Golden Chamber,certain regularities were found,in order to provide some reference for the wider clinical application of the“couplet medicines”prescriptions,the in-depth study of the pharmacodynamic mechanism and the development of new Chinese medicine based on ancient prescriptions.
作者
张云波
吴威
周佳欣
陈智慧
张会永
ZHANG Yunbo;WU Wei;ZHOU Jiaxin;CHEN Zhihui;ZHANG Huiyong(Key Laboratory of Ministry of Education for Traditional Chinese Medicine Viscera State Theory and Applications,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Zhuhai College of Science and Technology,Zhuhai 519041,Guangdong,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)
出处
《辽宁中医药大学学报》
CAS
2024年第12期146-151,共6页
Journal of Liaoning University of Traditional Chinese Medicine
基金
辽宁省自然科学基金项目(2022-NLTS-13-05)
广东省自然科学基金项目(2021A1515011485)
沈阳市中青年科技创新人才支持项目计划项目(RC190281)。
关键词
药对
“对药”方剂
《伤寒论》
《金匮要略》
用药分析
couplet medicines
“couplet medicines”prescription
Treatise on Febrile Diseases
Synopsis of the Golden Chamber
drug use analysis
