摘要
近年来研究表明肝脏疾病和肠道菌群之间的关系密切,非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)、慢性肝炎、肝硬化等肝病患者均有不同程度的肠道菌群失调。肠道菌群的组成、丰度异常会影响肠道菌群代谢物,肠道屏障功能破坏会增加细菌、脂多糖、内毒素等进入肝脏,进而促进肝脏炎症反应、加重肝脏负荷,导致脂质沉积。同时,胆固醇诱导的NAFLD的形成与肠道微生物群的生物学紊乱有关,肝脏中的解毒途径被削弱,其代谢产物又可破坏肠道微生态,致肠道菌群结构紊乱,影响肠黏膜修复作用、损害屏障功能。肝损伤亦可进一步导致肠道通透性改变和全身炎症反应。由此形成恶性循环、相互作用,参与NAFLD的发生、发展。而加强对肠道微生物群及其相关代谢物的抑制,则可能是预防NAFLD的有效策略。该文从与肠道菌群关联性探讨NAFLD的研究进展,通过重建肠道微生态平衡、菌群移植治疗、针对影响菌群的抗生素适宜治疗等方式,可以延缓NAFLD病变进展。
In recent years,research has shown a close relationship between liver diseases and gut microbiota.Patients with non-alcoholic fatty liver disease(NAFLD),chronic hepatitis,cirrhosis,and other liver diseases all have varying degrees of gut microbiota imbalance.The abnormal composition and abundance of gut microbiota can affect the metabolites of gut microbiota.The disruption of gut barrier function can increase the entry of bacteria,lipopolysaccharides,endotoxins,and other substances into the liver,thereby promoting liver inflammation,increasing liver load,and leading to lipid deposition.At the same time,the formation of cholesterol induced NAFLD is related to the biological disruption of the gut microbiota.The detoxification pathways in the liver are weakened,and its metabolites can disrupt the gut microbiota,leading to structural disorders of the gut microbiota,affecting the repair function of the intestinal mucosa,and damaging the barrier function.Liver injury can further lead to changes in intestinal permeability and systemic inflammatory response.This forms a vicious cycle and interaction,participating in the occurrence and development of NAFLD.Strengthening the inhibition of gut microbiota and its related metabolites may be an effective strategy for preventing NAFLD.This article explores the research progress of NAFLD from the perspective of its association with gut microbiota,by rebuilding the balance of gut microbiota,microbiota transplantation therapy,and appropriate antibiotic treatment targeting the affected microbiota,the progression of NAFLD can be delayed.
作者
葛阳
岳晓蕾
王恩行
吴长亮
王振常
GE Yang;YUE Xiaolei;WANG Enxing;WU Changliang;WANG Zhenchang(Guangxi University of Chinese Medicine,Nanning 530200,Guangxi,China;Sanya Hospital of Traditional Chinese Medicine,Sanya 572000,Hainan,China;Guangxi International Zhuang Medical Hospital,Nanning 530201,Guangxi,China)
出处
《辽宁中医药大学学报》
CAS
2024年第12期103-107,共5页
Journal of Liaoning University of Traditional Chinese Medicine
基金
国家自然科学基金(81960910)
广西壮族自治区自然重点项目(81660745)
广西中医药管理局基金项目(GZSY21-45)
广西中医药多学科交叉创新团队资助项目(GZKJ2311)。
关键词
非酒精性脂肪肝病
肠道菌群
研究进展
non-alcoholic fatty liver disease
intestinal flora
research progress
