摘要
目的评价泽茵丸在非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)患者治疗中的可行性,及对患者肠道菌群、血脂水平、肝酶指标的影响。方法收集2022年1月至2023年12月陕西省中医医院肝病血液科收治的NAFLD患者共80例,随机数字表法分为对照组(n=40)和观察组(n=40)。对照组予以常规西药治疗,观察组在常规西药治疗基础上增用泽茵丸。比较两组治疗3个月后总有效率、肠道菌群、血脂、肝酶指标动态变化及治疗期间不良反应发生率。结果治疗3个月后,观察组总有效率(97.50%)高于对照组(77.50%,P<0.05)。治疗3个月后,观察组双歧杆菌、乳酸杆菌数高于对照组,大肠杆菌数低于对照组(P<0.05)。治疗3个月后,观察组LDL-C、TC水平低于对照组,HDL-C水平高于对照组(P<0.05)。治疗3个月后,观察组ALT、AST、γ-GGT水平均低于对照组(P均<0.05)。治疗期间,观察组不良反应发生率(12.50%)与对照组(5.00%)比较,差异无统计学意义(P>0.05)。结论泽茵丸治疗NAFLD疗效显著,能改善患者肠道菌群分布,调节血脂水平,降低肝酶指标水平,促进肝功能的恢复,治疗期间未明显增加药物不良反应,值得借鉴。
Objective To evaluate the feasibility of Zeyin pill in treating patients with non-alcoholic fatty liver disease(NAFLD)and its effects on intestinal flora,lipid levels,and liver enzyme indicators.Methods A total of 80 NAFLD patients admitted to the Department of Hepatology and Hematology,Shaanxi Provincial Hospital of Traditional Chinese Medicine from Jan.2022 to Dec.2023 were recruited.They were randomly divided into control group(n=40)and observation group(n=40)using a random numeric table.The control group received conventional Western medicine treatment,while the observation group was additionally treated with Zeyin pill.After 3 months of treatment,the total effective rate,dynamic changes in intestinal flora,blood lipid levels,liver enzyme indexes,and the incidence of adverse reactions between the two groups were compared.Results After 3 months of treatment,the total effective rate in the observation group(97.50%)was significantly higher than that in the control group(77.50%,P<0.05).The number of bifidobacteria and lactobacillus in the observation group was greater,while the number of Escherichia coli was lower compared to the control group(P<0.05).Additionally,after 3 months,levels of LDL-C and TC in the observation group were lower,and HDL-C levels were higher than those in the control group(P<0.05).Levels of ALT,AST,and γ-GGT in the observation group were also lower than those in the control group(all P<0.05).During the treatment period,the incidence of adverse reactions was 12.50% in the observation group compared to 5.00% in the control group,with no statistically significant difference(P>0.05).Conclusion The efficacy of Zeyin pill in treating NAFLD is remarkable;they can improve the distribution of intestinal flora,regulate blood lipid levels,reduce liver enzyme indicators,and promote recovery of liver function.Furthermore,there is no significant increase in adverse drug reactions during the treatment period,indicating its potential for clinical application.
作者
刘皎皎
李粉萍
杨跃青
何瑾瑜
叶苗青
曹雪艳
王红
LIU Jiaojiao;LI Fenping;YANG Yueqing;HE Jinyu;YE Miaoqing;CAO Xueyan;WANG Hong(Department of Hepatology and Hematology,Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xi′an 710000,China)
出处
《胃肠病学和肝病学杂志》
2025年第9期1328-1333,共6页
Chinese Journal of Gastroenterology and Hepatology
基金
陕西省自然科学基础研究计划项目(2023-JC-QN-0977)。
关键词
非酒精性脂肪性肝病
泽茵丸
肠道菌群
血脂水平
肝酶指标
治疗期间不良反应
Non-alcoholic fatty liver disease
Zeyin pill
Intestinal flora
Blood lipid level
Liver enzyme index
Adverse reaction during the treatment period
