摘要
Friedel-Crafts烷基化反应是一类重要的有机人名反应,常用于构建碳-碳键,在有机合成及药物化学等领域具有广泛的应用前景。本文介绍了Friedel-Crafts烷基化反应的基本原理,以及近年来利用金属催化、有机小分子催化、可见光催化、酶催化和电化学催化等策略所取得的新发展。将本科教学知识与前沿研究有机结合,有利于提高学生的学习兴趣,培养学生思维拓展能力。
The Friedel-Crafts alkylation reaction represents a pivotal organic transformation for the formation of carbon-carbon bonds,holding extensive applications within the realms of both organic synthesis and pharmaceutical chemistry.This article presents a comprehensive review of the mechanism underlying the Friedel-Crafts alkylation reaction,alongside recent advancements in various catalytic approaches,such as metal catalysis,organocatalysis,visible light photocatalysis,enzymatic and electrochemical catalysis.By merging cutting-edge scientific developments with undergraduate teaching content,this review endeavors to inspire students’learning interests while fostering their capacity for innovative thinking.
作者
程诗砚
阮永红
龚磊
林玉妹
Shiyan Cheng;Yonghong Ruan;Lei Gong;Yumei Lin(College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,Fujian Province,China)
出处
《大学化学》
CAS
2024年第10期408-415,共8页
University Chemistry
基金
国家自然科学基金面上项目(22371237,22071209,22071206)。
