摘要
生脉散来源于金代张元素的《医学启源》,能补肺中元气不足,具有益气养阴、止汗生津的功效,为治心系疾病之妙药,临床上广泛运用于心系疾病的治疗。本文对生脉散治疗心系疾病的临床、基础研究与作用机制进行了综述,发现生脉散在治疗冠心病、心力衰竭、病毒性心肌炎、心律失常、扩张型心肌病等心系疾病中具有较好的疗效,其作用机制可能与抗氧化应激、调控与心肌纤维化相关的细胞因子及蛋白质水平、抑制神经内分泌系统、消除炎症反应、改善线粒体功能等有关。本文可为生脉散治疗心系疾病的临床推广及进一步开发利用提供参考。
Sheng-Mai-San(SMS)has its origin in Zhang Yuansu's work“The Origin of Medicine”during the Jin Dynasty.It is known for its ability to address lung vital energy deficiencies,nourish qi and yin,halt sweating,and promote fluid generation.Due to its efficacy in treating heart ailments,SMS is extensively utilized in clinical settings for heart disease management.This review outlined the clinical studies and mechanisms of SMS in the context of cardiovascular disease treatment.Our research indicated that SMS demonstrates positive therapeutic outcomes in managing various cardiovascular conditions including coronary heart disease,heart failure,viral myocarditis,arrhythmia,and dilated cardiomyopathy.The potential mechanisms underlying its efficacy may involve antioxidant properties,modulation of cytokines and proteins associated with myocardial fibrosis,suppression of the neuroendocrine system,mitigation of inflammatory responses,and enhancement of mitochondrial function.These findings offer valuable insights for the advancement and application of SMS in clinical practice for cardiovascular disease treatment.
作者
易鑫颖
周宇轩
彭添凤
滕瑄
宋厚盼
YI Xinying;ZHOU Yuxuan;PENG Tianfeng;TENG Xuan;SONG Houpan(College of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Provincial Key Laboratory of TCM Diagnostics,Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《生命的化学》
CAS
2024年第8期1376-1383,共8页
Chemistry of Life
基金
国家自然科学基金项目(82374429)
湖南省自然科学基金项目(2023JJ30460)
湖湘青年科技创新人才项目(2021RC3101)
刘良院士工作站指导项目(22YS003)
湖南中医药大学本科生科研创新基金项目(2023BKS156,2023BKS162)。
关键词
生脉散
心系疾病
临床应用
中医药治疗
Sheng-Mai-San
heart system disease
clinical application
traditional Chinese medicine treatment收
