摘要
目的探索重症监护室医务人员接种三剂新型冠状(新冠)病毒灭活疫苗后抗新冠病毒抗体动态变化情况,并动态评估其免疫状态。方法选取2020年11月至2021年11月在该院接种了三剂新冠病毒灭活疫苗的重症监护室医务人员30名作为研究对象,采集接种新冠病毒疫苗后0、1、3、6、12个月静脉血检测抗新冠病毒抗体免疫球蛋白G滴度、淋巴细胞亚群、细胞因子等,并分析其变化情况。结果30名医务人员注射三剂新冠病毒灭活疫苗后1个月抗新冠病毒抗体均为阳性,第1个月滴度明显升高,差异有统计学意义(P<0.05);第1个月抗新冠病毒抗体达到高峰后逐步下降,第12个月抗新冠病毒抗体较第0个月仍高,差异有统计学意义(P<0.05)。不同时间点各淋巴细胞亚群比较,差异无统计学意义(P>0.05)。接种新冠病毒灭活疫苗后白细胞介素-2(IL-2)、IL-10、γ干扰素、肿瘤坏死因子α均呈倒U型变化,IL-6呈U型变化,IL-4呈波动型变化。结论接种三剂灭活疫苗后可产生更高的抗体水平,并可维持高滴度最少6个月以上。
Objective To explore the dynamic changes of anti-coronavirus antibodies in medical staff of intensive care unit after three doses of novel coronavirus inactivated vaccine,and to dynamically evaluate their immune status.Methods A total of 30 medical staff in intensive care unit who received three doses of inactivated SARS-CoV-2 vaccine in this hospital from November 2020 to November 2021 were selected as the research objects.Venous blood samples were collected at 0,1,3,6 and 12 months after inoculation of novel coronavirus vaccine to detect the titer of anti-novel,coronavirus antibody immunoglobulin G,lymphocyte subsets and cytokines,and the changes were analyzed.Results Anti-coronavirus antibodies were positive in 30 medical staff one month after injection of three doses of inactivated coronavirus vaccine,and the titer increased significantly in the first month,with statistically significant difference(P<0.05).In the first month,the anti-neo-coronavirus antibody reached a peak and then gradually decreased.In the 12th month,the anti-neo-coronavirus antibody was still higher than that in the 0 th month,and the difference was statistically significant(P<0.05).There was no significant difference in lymphocyte subsets at different time points(P>0.05).After inoculation with the novel coronavirus inactivated vaccine,interleukin-2(IL-2),IL-10,interferon-γ,and tumor necrosis factor-αall showed inverted U-shaped changes,IL-6 showed U-shaped changes,and IL-4 showed fluctuating changes.Conclusion The three-dose inactivated vaccine can produce a higher level of antibody and maintain a high titer for at least six months.
作者
张盛果
周宇
张伟伟
阮战伟
ZHANG Shengguo;ZHOU Yu;ZHANG Weiwei;RUAN Zhanwei(Department of Infectious Diseases,the Third Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China;Department of Emergency,the Third Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China)
出处
《现代医药卫生》
2024年第17期2911-2914,2919,共5页
Journal of Modern Medicine & Health
基金
浙江省瑞安市科技局科技项目(MS2021039,MS2021040)。
关键词
新型冠状病毒
灭活疫苗
抗体
动态变化
Novel coronavirus
Inactivated vaccine
Antibody
Dynamic changes
