摘要
膝骨关节炎(KOA)是临床常见的退行性骨关节病,晚期可导致关节功能丧失,具有高致残率的特点,目前尚无一种有效的根治方法。中药外用制剂具有悠久的发展历史及独特优势,其在KOA治疗中发挥着重要作用。传统外用中药制剂具有制备工艺简单、载药量大等特点,而现代外用中药制剂在提高透皮吸收性、降低皮肤刺激性、药效持久性、增加生物相容性、使用便捷性等方面具有显著优势。然而,两者在制备工艺、药效发挥及使用安全性等方面仍存在一些局限。文章通过归纳相关文献,论述中药传统和现代外用制剂在KOA治疗中的应用现状,分析外用中药制剂存在的关键问题,提出改进制备工艺流程、结合现代技术创新给药方式及改进剂型等可能是今后潜在研究方向,以期更加安全、有效地治疗KOA。
Knee osteoarthritis(KOA)is a common degenerative osteoarthropathy in clinical practice,which can lead to loss of joint function in the late stage and has a high disability rate.At present,there is no effective radical cure treatment.Topical preparations of traditional Chinese medicine have a long history of development and unique advantages,which play an important role in the treatment of KOA.The traditional method for topical preparations of traditional Chinese medicine has the characteristics of simple preparation process and large drug loading,while modern method for topical preparations of traditional Chinese medicine has significant advantages in improving transdermal absorption,reducing skin irritation,enhancing the efficacy durability,increasing biocompatibility,and improving use convenience.However,there are still some limitations in the preparation process,efficacy performance and use safety of the two drugs.Summarizing relevant literatures,this paper discussed the topical preparations of traditional and modern methods of traditional Chinese medicine in the application status of KOA treatment,and analyzed the key problems of topical preparations of traditional Chinese medicine,and suggested that improving the preparation process,standardization of clinical use,combining with modern technology to create new ways of drug delivery and improving formulations could be a potential research direction in the future,to treat KOA more safely and effectively.
作者
郭天赐
赵杨
陈继鑫
余伟杰
张阳
刘爱峰
王平
GUO Tianci;ZHAO Yang;CHEN Jixin;YU Weijie;ZHANG Yang;LIU Aifeng;WANG Ping(Department of Traumatology&Orthopedics,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center of Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;College of Pharmaceutical Engineering of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)
出处
《天津中医药》
CAS
2024年第8期1083-1088,共6页
Tianjin Journal of Traditional Chinese Medicine
基金
天津市名中医传承工作室建设项目(881022)
国家自然科学基金面上项目(81873316)
天津市科技计划项目(23KPXMRC00170)。
关键词
膝骨关节炎
中药外用制剂
黑膏药
凝胶贴膏
knee osteoarthritis
topical preparations of traditional Chinese medicine
black plaster
gel plaster
