摘要
根据目前WHO消化系统肿瘤分类中的分级标准,胃肠胰神经内分泌肿瘤可分为低、高级别肿瘤,其中高级别肿瘤包括了分化良好的神经内分泌瘤G3和低分化神经内分泌癌。两者临床病理特征和治疗决策显著不同,是病理诊断工作中的难点。如何较为精准地区分至关重要。全文归纳总结了目前研究中所涉及的这两类肿瘤病理诊断标准以及相关免疫组化、分子标志物研究进展,旨在为临床正确认识该类疾病并制定适宜的精准治疗方案提供更可靠的依据。
Gastroenteropancreatic neuroendocrine neoplasm(GEP-NEN) are classified into lowgrade and high-grade tumors according to the WHO classification criteria for digestive system tumors.The high-grade NEN include well differentiated neuroendocrine tumor G3 and poorly differentiated neuroendocrine cancer.The clinical pathological characteristics and treatment options of the two are significantly different,however,it is difficult in differential diagnosis pathologically.This paper summarizes the current pathological diagnostic criteria and research progress on immunohistochemical and molecular marker of these two types of tumors,to provide reference for the development of appropriate treatment plans.
作者
吴晓晓
许晶晶
朱利明
吴伟
WU Xiaoxiao;XU Jingjing;ZHU Liming;WU Wei(Zhejiang Cancer Hospital,Hangzhou Institute of Medicine(HIM),Chinese Academy of Sciences)
出处
《肿瘤学杂志》
CAS
2024年第5期353-359,共7页
Journal of Chinese Oncology
基金
浙江省医药卫生科技临床研究应用项目(2022KY103)。
关键词
胃肠胰肿瘤
神经内分泌瘤
神经内分泌癌
病理诊断
gastroenteropancreatic neoplasm
neuroendocrine tumor
neuroendocrine carcinoma
pathological diagnosis
