摘要
目的 探讨涎腺腺样囊性癌(SACC)组织中PCNP、转化生长因子β1(TGF-β1)表达及与其临床病理特征的关系。方法 选取58例SACC患者,所有患者行手术治疗,术中采集癌组织及癌旁正常组织送检,采用免疫组化SP染色法检测两种组织内PCNP、TGF-β1阳性表达情况,并分析PCNP、TGF-β1表达与患者年龄、性别、体质量指数、肿瘤位置、淋巴结转移、肿瘤大小、神经侵犯的关系。结果 癌组织内PCNP、TGF-β1阳性表达率高于对照组,差异有统计学意义(P<0.05);PCNP阳性、TGF-β1阳性患者肿瘤大小≥3 cm、神经侵犯占比高于PCNP阴性、TGF-β1阴性者,差异有统计学意义(P<0.05);PCNP阳性、TGF-β1阳性患者年龄、性别、体质量指数、肿瘤位置、淋巴结转移情况与PCNP阴性、TGF-β1阴性患者相比,差异无统计学意义(P>0.05)。结论 PCNP、TGF-β1在SACC组织内表达较高,与肿瘤大小、神经侵犯存在密切关系,或可为临床治疗提供新的方向。
Objective To explore the expression of PCNP and TGF-β1 in salivary adenoid cystic carcinoma(SACC)tissues and its relationship with clinical pathological characteristics.Methods 58 SACC patients were selected,and all patients underwent surgical treatment.During the surgery,cancer tissue and adjacent normal tissue were collected for examination.Immunohistochemical SP staining was used to detect positive expression of PCNP and TGF-β1 in both tissues.The relationship between expression of PCNP and TGF-β1 and patients'age,gender,body mass index,tumor location,lymph node metastasis,tumor size,and nerve invasion were analyzed.Results The positive expression rate of PCNP and TGF-β1 in cancer tissues was higher in the control group,and the difference was statistically significant(P<0.05);PCNP positive,TGF-β1 positive patients with tumor size≥3 cm,and nerve invasion had higher proportion than PCNP negative and TGF-β1 negative patients,the difference is statistically significant(P<0.05);Age,gender,body mass index,tumor location,lymph node metastasis status of PCNP and TGF-β1 positive patients and PCNP and TGF-β1 negative patients,the difference was not statistically significant(P>0.05).Conclusion PCNP and TGF-β1 is highly expressed in SACC tissue,and closely related to tumor size and neural invasion,and may provide new directions for clinical treatment.
作者
黄菊芳
张玉杰
李蓓
单林霞
张璐
HUANG Jufang;ZHANG Yujie;LI Bei(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)
出处
《实用癌症杂志》
2024年第7期1126-1128,共3页
The Practical Journal of Cancer
关键词
涎腺腺样囊性癌
转化生长因子Β1
核蛋白PCNP
临床表达
病理特征
Adenoid cystic carcinoma of the salivary gland
Transforming growth factorβ1
Nuclear protein PCNP
Clinical expression
Pathological characteristics
