摘要
血醇检测是法医毒物实验室最常见的检测项目,结果的准确性至关重要。HS-GC检测目标物乙醇时,色谱图偶尔会出现乙醇之外的非目标物色谱峰,其中有些物质(如丙酮或七氟烷等)会通过影响乙醇或内标物峰面积干扰血醇结果判定,有些物质(如正丙醇、异丙醇和正丁醇等)的出现提示血样检材可能异常等。本文对实际血醇测定工作中出现的非目标物色谱峰进行质谱定性,进一步探讨气相色谱-质谱法在血醇司法鉴定领域的必要性。
Blood alcohol test was the most common test item in forensic toxicology laboratory,and the accuracy of the results was crucial.When the target substance alcohol was used to be detected by HS-GC,the chromatogram will occasionally showed peaks of non-target substances other than alcohol,among which some substances(such as acetone or sevoflurane,etc.)would interfere with the determination of blood alcohol results by affecting the peak area of alcohol or internal standard,and the appearance of some substances(such as n-propanol,isopropyl alcohol and n-butanol,etc.)indicates that the blood sample maid be abnormal.The chromatographic peaks of non-target substances appearing in the actual blood alcohol determination were analyzed qualitatively by mass spectrometry,and the necessity of gas chromatography-mass spectrometry in the field of blood alcohol forensic identification was further discussed in this article.
作者
党华
卢丝洁
顾风华
周冠仁
陈凤清
DANG Hua;LU Si-jie;GU Feng-hua;ZHOU Guan-ren;CHEN Feng-qing(Shanghai Fenglin Forensic Medical Center,Shanghai 200231,China)
出处
《广州化工》
CAS
2024年第6期134-138,共5页
GuangZhou Chemical Industry
关键词
法医毒理学
血液
乙醇
气相色谱-质谱法
顶空气相色谱法
forensic toxicology
blood
alcohol
gas chromatograph-mass spectrometry
headspacegas chromatography
