摘要
目的对巴西酒神菊Baccharis trimera(Less.)DC乙酸乙酯部位的化学成分进行研究。方法巴西酒神菊乙酸乙酯部位采用大孔树脂D101、Sephadex LH-20凝胶、硅胶等多种色谱技术进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到23个化合物,分别鉴定为15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oicacid(1),13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid(2),methyltrineracetal(3),epimethyltrineracetal(4),trinerolide(5),15-epitrinerolide(6),18-methylmalonyl-7α-hydroxy-methyltrineracetal(7),18-methylmalonyl-7α-hydroxy-epimethyltriner-acetal(8),18-methylmalonyl-methyltrineracetal(9),18-methylmalonyl-epi-methyltrineracetal(10),methy 3,5-dicaffeoylquinate(11),8-dimetho-xyflavone(12),4′,7-dihydroxy-5-methoxyflavanone(13),4-(3′,4′-dihydroxycinnamoyl)-oxy-methylcinnamate(14),3′,7-dihydroxy-4′,6,8-trimethoxy-flavone(15),erigeroflavanone(16),nepetin(17),4,2′,4′,β-tetrahydroxy-6′-methoxy-α,β-dihydrochalcone(18),eugenyl-O-β-D-glucoside(19),7-hydroxyl-5,6,3′,4′-tetramethoxylflavone(20),phomoxanthone J(21),18-acetyl-7α-hydroxy-methyltrineracetal(22),18-acetyl-7α-hydroxy-epimethyltrineracetal(23)。结论化合物3~10,22~23为首次从巴西酒神菊中分离的差向异构体,化合物11~16,18~21为首次从酒神菊属植物中分离得到。
AIM To study the chemical constituents from the ethyl acetate fraction of Baccharis trimera(Less.)DC.METHODS The ethyl acetate fraction of B.trimera was isolated and purified by macroporous resin D101,Sephadex LH-20 gel,silica gel and other chromatographic techniques,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Twenty-three compounds were isolated and identified as 15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid(1),13-epi-15,16-epoxy-15α-methoxy-ent-clerod-3-en-18-oic acid(2),methyltrineracetal(3),epimethyltrineracetal(4),trinerolide(5),15-epitrinerolide(6),18-methylmalonyl-7α-hydroxy-meth-yltrineracetal(7),18-methylmalonyl-7α-hydroxy-epimethyltriner-acetal(8),18-methylmalonyl-methyltrineracetal(9),18-methylmalonyl-epi-methyltrineracetal(10),methy 3,5-dicaffeoylquinate(11),8-dimetho-xyflavone(12),4′,7-dihydroxy-5-methoxyflavanone(13),4-(3′,4′-dihydroxycinna-moyl)-oxy-methy-lcinnamate(14),3′,7-dihydroxy-4′,6,8-trimethoxy-flavone(15),erigeroflavanone(16),nepetin(17),4,2′,4′,β-tetrahydroxy-6′-methoxy-α,β-dihydrochalcone(18),eugenyl-O-β-D-glucoside(19),7-hydroxyl-5,6,3′,4′-tetramethoxylflavone(20),phomoxanthone J(21),18-acetyl-7α-hydroxy-methyltrineracetal(22),18-acetyl-7α-hydroxy-epimethyltrineracetal(23).CONCLUSION Compounds 3-10 and 22-23 are epimers isolated from this plant for the first time.Compounds 11-16,18-21 are first isolated from genus Baccharis.
作者
梁勇
周小青
唐琍萍
高雪梅
颜冬梅
陈笑天
徐典
李斌
刘宏栋
LIANG Yong;ZHOU Xiao-qing;TANG Li-ping;GAO Xue-mei;YAN Dong-mei;CHEN Xiao-tian;XU Dian;LI Bin;LIU Hong-dong(Academician Workstation,Jiangxi University of Chinese Medicine,Nanchang 330004,China)
出处
《中成药》
CAS
CSCD
北大核心
2024年第6期1906-1913,共8页
Chinese Traditional Patent Medicine
基金
中央本级重大增减支项目(2060302-2101-10,2060302-2101-11)
江西中医药大学院士工作站项目(ysgzz201802)
江西中医药大学一流学科项目(JXSYLXK-ZHY0143)。
关键词
巴西酒神菊
乙酸乙酯部位
化学成分
分离鉴定
Baccharis trimera(Less.)DC
ethyl acetate fraction
chemical constituents
isolation and identification
