摘要
肿瘤微环境包括肿瘤病变部位和附近的血管、淋巴、神经、非恶性细胞及其代谢物等,肿瘤微环境与癌细胞相互作用,并促进癌症的进展。癌细胞快速增殖增加耗氧量或实体瘤内血管结构和功能的异常导致氧气供养量减少,形成缺氧微环境。缺氧微环境的存在是局部晚期实体瘤的典型病理生理特征,广泛存在于人类各类恶性肿瘤中,是肿瘤微环境的标志,也是乳腺肿瘤微环境中重要而复杂的系统,其形成和发展与乳腺癌的生长密切相关,在乳腺癌的研究和治疗中占据重要地位。中药有效单体与复方以其多通路、多靶点的优势,可以较好地调节乳腺癌的缺氧微环境,通过抑制缺氧环境下乳腺癌细胞的增殖、侵袭和转移、并诱导凋亡、逆转其耐药性、干预缺氧环境下乳腺癌细胞代谢重编程和抑制其血管生成等,从而在一定程度上提高患者的生存质量,延长患者的生存周期。该文先总结并论述缺氧微环境通过对乳腺癌细胞增殖、侵袭、转移、耐药、免疫功能、代谢重编程、非编码RNA、铁死亡和自噬的作用,影响乳腺癌的发生与发展,并详细阐述了其背后的作用机制,再基于中药有效单体与中药复方这两种用药模式,阐释其靶向缺氧微环境的调控作用与机制,以期分析与提炼出中药在调控缺氧微环境上的不足与方向,为乳腺癌的有效治疗提供理论参考。
The tumor microenvironment includes blood vessels,lymph,nerves,non-malignant cells and their metabolites at and near the tumor lesion site,which interact with cancer cells and promote cancer progression.Rapid proliferation of cancer cells increases oxygen consumption or abnormalities in the structure and function of blood vessels in solid tumors lead to a decrease in oxygen supply and the formation of a hypoxic microenvironment.The existence of hypoxic microenvironment is a typical pathophysiological feature of locally advanced solid tumors,widely present in various types of human malignant tumors,is a sign of tumor microenvironment,and is also an important and complex system in the breast tumor microenvironment,its formation and development is closely related to the growth of breast cancer,and occupies an important position in the research and treatment of breast cancer.With its advantages of multiple pathways and multiple targets,the effective monomer and compound of traditional Chinese medicine can better regulate the hypoxia microenvironment of breast cancer,inhibit the proliferation,invasion and metastasis of breast cancer cells in the hypoxic environment,induce apoptosis,reverse their drug resistance,intervene in the metabolic reprogramming of breast cancer cells in the hypoxic environment and inhibit their angiogenesis,etc.,thereby improving the quality of life of patients to a certain extent and prolonging the survival cycle of patients.This paper first summarizes and discusses the effects of hypoxia microenvironment on breast cancer cell proliferation,invasion,metastasis,drug resistance,immune function,metabolic reprogramming,non-coding RNA,iron death and autophagy,affects the occurrence and development of breast cancer,and elaborates the mechanism behind it,and then elucidates the regulatory effect and mechanism of targeting the hypoxia microenvironment based on the two modes of effective monomer of traditional Chinese medicine and traditional Chinese medicine compound,in order to analyze and extract the deficiencies and directions of traditional Chinese medicine in regulating the hypoxia microenvironment.Provide a theoretical reference for the effective treatment of breast cancer.
作者
王馨楠
胡文秀
孙硕
张文洁
赵益
孙有智
WANG Xinnan;HU Wenxiu;SUN Shuo;ZHANG Wenjie;ZHAO Yi;SUN Youzhi(College of Traditional Chinese Medicine(TCM),Formula-Pattern Research Center,Research Center of Differentiation and Development of TCM Basic Theory,Jiangxi University of Chinese Medicine,Nanchang 330004,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第12期232-241,共10页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(82060868,82360961)
江西省中医药骨干人才培养项目(赣中医药科教字[2021]4号)
江西省教育厅科学技术研究项目(GJJ2200907)
江西中医药大学校级科技创新团队发展计划(CXTD22007,CXTD22008)
熊墨年国医名师传承工作室建设项目(赣中医药综合字[2021]12号)。
关键词
缺氧微环境
乳腺癌
中药有效单体
中药复方
综述
hypoxia
breast cancer
effective monomers of traditional Chinese medicine
herbal formula
review
