摘要
细胞衰老和纤维化是两个与许多疾病发展密切相关的生物学过程。细胞衰老可通过端粒缩短、DNA损伤和氧化应激等机制发生,导致细胞功能退化和损伤修复能力下降。越来越多的研究表明,纤维化和细胞衰老的关系密不可分,细胞衰老已被证实参与瘢痕纤维化疾病的发生发展。深入理解细胞衰老与瘢痕纤维化的关系有助于寻找新的治疗策略和开发靶向性药物来减轻瘢痕纤维化进程。
Cellular senescence and fibrosis are two biological processes that are closely related to the development of many diseases.Cellular senescence can occur through mechanisms such as telomere shortening,DNA damage,and oxidative stress,leading to degradation of cell function and decreased ability to repair damage.More and more studies have shown that fibrosis and cell senescence are closely related,and cell senescence has been confirmed to be involved in the occurrence and development of scar fibrosis diseases.An in-depth understanding of the relationship between cellular senescence and scar fibrosis is helpful to find new therapeutic strategies and develop targeted drugs to reduce the process of scar fibrosis.
作者
安靖雯
冯俊云
饶磊
刘德伍
AN Jingwen;FENG Junyun;RAO Lei;LIU Dewu(Medical Center for Burns,Plastic Surgery and Wound Repair,the 1^(st)Affiliated Hospital of Nanchang University,Nanchang 330006,China)
出处
《实用医学杂志》
CAS
北大核心
2024年第12期1749-1754,共6页
The Journal of Practical Medicine
基金
国家自然科学基金(编号:82160378)。
关键词
细胞衰老
瘢痕纤维化
靶向药物
cellular senescence
fibrosis of scar
targeted therapy
