摘要
帕金森病(Parkinson's disease,PD)是一种常见的神经系统退行性疾病,发病机制复杂,大量研究表明线粒体功能障碍是PD的重要致病因素,而线粒体质量控制失调是导致线粒体功能障碍的关键因素,线粒体生物发生异常,融合/裂变失衡和线粒体过度自噬化与PD的发病具有紧密联系,但线粒体质量控制系统在PD进展中的作用尚不清晰。本文就线粒体质量控制系统在PD中作用机制进行综述,以期为PD的临床预防和治疗提供新的思路和理论基础。
Parkinson's disease(PD)is a common neurodegenerative disease with a complex pathogenesis,and a large number of studies have shown that mitochondrial dysfunction is an important causative factor for PD,whereas dysregulation of mitochondrial quality control is a key factor leading to mitochondrial dysfunction,and that aberrant mitochondrial biogenesis,fusion/fission imbalance,and mitochondrial hyperautophagy are closely associated with the onset of PD,but the role of the mitochondrial quality control system in the progression of PD is unclear.Therefore,this paper reviews the mechanism of mitochondrial quality control system in PD,with the aim of providing new ideas and theoretical basis for the clinical prevention and treatment of PD.
作者
刘娟
李彦杰
秦合伟
马璐瑶
赵楠楠
丁慧敏
LIU Juan;LI Yanjie;QIN Hewei;MA Luyao;ZHAO Nannan;DING Huimin(Henan University of Chinese Medicine,Zhengzhou 450046,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2024年第11期1479-1482,共4页
The Journal of Practical Medicine
基金
河南省中医药拔尖人才培养项目(编号:豫卫中医涵[2021]15号)
“张仲景传承与创新专项”专项课题(编号:GZY-KJS-2022-043-3)
中原英才计划中原青年拔尖人才项目(编号:豫组通[2021]44号)。
关键词
帕金森病
线粒体质量控制
线粒体生物发生
线粒体动力学
线粒体自噬
Parkinson's disease
mitochondrial quality control
mitochondrial biogenesis
mitochondrial dynamics
mitochondrial autophagy
