摘要
目的研究代谢综合征合并缺血性脑卒中的中医状态辨识。方法收集2021年3月-2023年6月在长春中医药大学附属医院的代谢综合征合并缺血性脑卒中患者的一般临床资料和四诊信息;采用隐结构模型进行分析。结果280例代谢综合征合并缺血性脑卒中患者,共纳入54个中医症状,分层建立54个隐类,综合聚类分别得到3个新的隐类。Z1主要以脾气虚和脾虚湿困为特点,辨为中满态;Z2多以为中焦湿热证和火热证为特点,辨为内热态;Z3以肝肾不足证和肝阳上亢证为主要特点,辨为下焦失藏态。结论代谢综合征合并缺血性脑卒中患者多以脾胃病变为基础,中焦运化失司作为代谢综合征的基本病机,下焦失藏是缺血性脑卒中发生发展的病机关键。
Objective To explore a TCM state identification system for the metabolic syndrome complicated wtih ischemic stroke.Methods Patients diagnosed with the metabolic syndrome complicated with ischemic stroke at the Affiliated Hospital of Changchun University of Chinese Medicine from March 2021 to June 2023 were investigated,and their general clinical data and the data gained by the four diagnostic methods were collected.Subsequently,the implicit structure model was employed for a data analysis.Results A total of 280 patients with the metabolic syndrome combined with ischemic stroke were enrolled,covering 54 TCM symptoms.Corresponding to these,54 latent classes were established,which were further grouped into three new latent classes through comprehensive clustering.Among them,latent class Z1 was characterized by the syndromes of spleen qi deficiency and dampness stagnancy due to spleen deficiency,categorized as a flatulence state in the middle jiao.Latent class Z2 primarily featured the syndromes of dampness-heat and fire-heat in the middle jiao,categorized as an endogenous heat state.Latent class Z3 was predominantly characterized by the syndromes of spleen and kidney deficiency and liver yang hyperactivity,categorized as a state of storage failure in the lower jiao.Conclusion Patients with the metabolic syndrome complicated with ischemic stroke are mostly based on spleen and stomach pathologies,with the failure in transportation and transformation in the middle jiao as the basic pathogenesis of metabolic syndrome,while with the storage dysfunction of the lower jiao as the key pathogenesis for the occurrence and development of ischemic stroke.
作者
王位
师雨晴
王立超
熊华忠
王梓旭
周航
王梦晨
任吉祥
WANG Wei;SHI Yuqing;WANG Lichao;XIONG Huazhong;WANG Zixu;ZHOU Hang;WANG Mengchen;REN Jixiang(Changchun University of Chinese Medicine,Changchun 130117,China;Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130021,China)
出处
《吉林中医药》
2024年第4期434-439,共6页
Jilin Journal of Chinese Medicine
基金
吉林省重大科技专项课题(20210304001YY)
吉林省科技发展计划项目(YDZJ202301ZYTS184)
吉林省中医药科技项目(2023132)。
关键词
代谢综合征
缺血性脑卒中
状态辨识
隐结构模型
metabolic syndrome
ischemic stroke
state identification
implicit structure model
