摘要
目的 探讨分析新生儿呼吸窘迫综合征(NRDS)采用经鼻同步间歇正压通气(NSIPPV)联合肺表面活性物质(PS)治疗的疗效。方法 将96例NRDS新生儿,按照随机抽取法分为两组,对照组使用NSIPPV,观察组在此基础上,使用PS治疗,比较两组临床疗效及并发症,治疗前后血气分析指标及各项治疗指标。结果 观察组治疗有效率为93.75%,明显高于对照组的77.08%(P<0.05);观察组肺出血、呼吸机相关性肺炎、气胸、心律失常、视网膜病变等并发症发生率明显低于对照组(P<0.05);观察组治疗后PaO_(2)、SaO_(2)、OI均高于对照组,PaCO_(2)低于对照组(P<0.05);观察组氧疗时间、症状消失时间、住院时间、气管插管率均小于对照组(P<0.05)。结论 新生儿NRDS采用NSIPPV联合PS治疗的疗效显著,能有效改善血气分析指标,加快病情缓解速度,降低气管插管率及并发症发生,有助改善预后,具有重要临床意义。
Objective To investigate and analyze the therapeutic effect of nasal synchronous positive intermittent pressure ventilation(NSIPPV)combined with pulmonary surfactant(PS)on neonates with respiratory distress syndrome(NRDS).Methods 96 neonates with NRDS who were treatedwere randomly divided into two groups by computer numerical table.The control group was treated with NSIPPV,and the observation group was treated with PS on this basis.The clinical efficacy and complications,blood gas analysis indexes before and after treatment and various treatment indexes of the two groups were compared.Results The effective rate of the observation group was 93.75%,which was significantly higher than that of the control group(77.08%,P<0.05);The incidence of complications such as pulmonary hemorrhage,ventilator-associated pneumonia,pneumothorax,arrhythmia and retinopathy in the observation group was significantly lower than that in the control group(P<0.05);After treatment,PaO_(2),SaO_(2) and OI in the observation group were higher than those in the control group,while PaCO_(2) was lower than that in the control group(P<0.05);The time of oxygen therapy,the time of symptom disappearance,the time of hospitalization and the rate of tracheal intubation in the observation group were less than those in the control group(P<0.05).Conclusion The therapeutic effect of NSIPPV combined with PS on NRDS neonates is significant,which can effectively improve the blood gas analysis indicators,speed up the remission of the disease,reduce the rate of tracheal intubation and complications,and help improve the prognosis.It has important clinical significance.
作者
陈田田
Chen Tiantian(Luohe Third People's Hospital NICU,Luohe462300,China)
出处
《哈尔滨医药》
2023年第6期38-40,共3页
Harbin Medical Journal
