摘要
目的:探讨阿托伐他汀联合氯吡格雷在短暂性脑缺血发作(TIA)中的应用效果。方法:选取2021年1—12月贵航贵阳医院收治80例TIA患者。根据抽样检测法将其分为对照组和观察组,各40例。对照组给予氯吡格雷治疗,观察组在对照组基础上给予阿托伐他汀治疗。比较两组临床疗效,治疗前后凝血功能及血脂指标、炎症因子、颈动脉斑块情况,治疗后3个月、6个月及12个月TIA发生率,不良反应。结果:观察组治疗总有效率(90.00%)高于对照组(72.50%),差异有统计学意义(P<0.05)。治疗后,两组凝血酶原时间(PT)、血小板计数(PLT)比较,差异无统计学意义(P>0.05),观察组甘油三酯(TG)、总胆固醇(TC)均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组超敏C反应蛋白(hsCRP)、白细胞介素-6(IL-6)水平均低于对照组,差异有统计学意义(P<0.05)。治疗后3个月、6个月及12个月,观察组TIA发生率低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组颈动脉斑块数、低回声斑块数、强回声斑块数均少于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(χ^(2)=0.139,P=0.709)。结论:阿托伐他汀联合氯吡格雷治疗TIA患者效果显著,利于减少脑缺血发作,改善炎症因子及血脂水平,稳定斑块。
Objective:To explore the application effect of Atorvastatin combined with Clopidogrel in transient ischemic attack(TIA).Method:A total of 80 patients with TIA admitted to Guihang Guiyang Hospital were selected from January to December 2021.They were divided into control group and observation group according to the sampling inspection method,40 cases in each group.The control group was treated with Clopidogrel,and the observation group was treated with Atorvastatin on the basis of control group.The clinical efficacy,coagulation function,blood lipid indexes,inflammatory factors,carotid plaque condition before and after treatment,incidence of TIA at 3 months,6 months and 12 months after treatment and adverse reactions were compared between the two groups.Result:The total effective rate of observation group(90.00%)was higher than that of control group(72.50%),and the difference was statistically significant(P<0.05).After treatment,there were no statistically significant in prothrombin time(PT)and platelet count(PLT)between the two groups(P>0.05),and triglyceride(TG)and total cholesterol(TC)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of hypersensitive C-reactive protein(hs-CRP)and interleukin-6(IL-6)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).At 3 months,6 months and 12 months after treatment,the incidences of TIA in observation group were lower than that in control group,and the differences were statistically significant(P<0.05).After treatment,the number of carotid plaque,low echo plaque and strong echo plaque in the observation group were lower than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(χ^(2)=0.139,P=0.709).Conclusion:Atorvastatin combined with Clopidogrel is effective in the treatment of TIA patients,which can reduce ischemic attacks,improve the levels of inflammatory factors and blood lipids,and stabilize plaques.
作者
李翔
LI Xiang(Guihang Guiyang Hospital,Guiyang 550003,China)
出处
《中外医学研究》
2023年第34期27-30,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
