摘要
目的探讨阿托伐他汀联合氯吡格雷治疗冠心病心绞痛临床疗效及对血脂、血液流变学、心功能影响。方法选取2019年4月至2020年8月萍乡市第二人民医院收治的133例冠心病心绞痛患者作为研究对象,按照信封法分为常规组(n=66)与研究组(n=67)。常规组给予常规治疗,研究组在常规组基础给予阿托伐他丁联合氯吡格雷治疗,比较两组治疗前后血脂[总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDL-C)]水平、血液流变学(红细胞压积、全血低切黏度、血液黏度)、心功能[射血分数(EF)、心脏每分搏出量(HMO)、心脏指数(CI)]。结果治疗后,两组TC、LDL-C水平均低于治疗前,HDL-C水平均高于治疗前,且研究组TC、LDL-C水平均低于常规组,HDL-C水平高于常规组,差异有统计学意义(P<0.05)。治疗后,两组红细胞压积均小于治疗前,全血低切黏度、血浆粘度均低于治疗前,且研究组红细胞压积小于常规组,全血低切黏度、血浆粘度均低于常规组,差异有统计学意义(P<0.05)。治疗后,两组EF、HMO、CI均高于治疗前,且研究组高于常规组,差异有统计学意义(P<0.05)。结论阿托伐他丁联合氯吡格雷治疗冠心病心绞痛患者,能有效患者降低血脂水平,改善其血液流变学,增强患者心功能,值得临床推广应用。
Objective To investigate the clinical efficacy of atorvastatin combined with clopidogrel in the treatment of angina pectoris of coronary heart disease and its effect on blood lipid,hemorheology and cardiac function.Methods A total of 133 patients with coronary heart disease and angina pectoris admitted to Pingxiang NO.2 People's Hospital from April 2019 to August 2020 were selected as the research subjects,and they were divided into the routine group(n=66)and the study group(n=67)according to the envelope method.The routine group was given routine treatment,and the study group was given atorvastatin combined with clopidogrel on the basis of the routine group.The levels of blood lipids(total cholesterol[TC],low density lipoprotein cholesterol[LDL-C],high density lipoprotein cholesterol[HDL-C]),hemorheology(hematocrit,whole blood low shear viscosity,blood viscosity),cardiac function(ejection fraction[EF],heart minute output[HMO],cardiac index[CI])were compared between the two groups before and after treatment.Results After treatment,the levels of TC and LDL-C in the two groups were lower than those before treatment,and the levels of HDL-C were higher than those before treatment,the levels of TC and LDL-C in the study group were lower than those in the routine group,and the level of HDL-C was higher than that in the routine group,the differences were statistically significant(P<0.05).After treatment,the hematocrit of the two groups was less than that before treatment,the whole blood low shear viscosity and plasma viscosity were lower than those before treatment,and the hematocrit in the study group was less than that in the routine group,the whole blood low shear viscosity and plasma viscosity were lower than those in the routine group,the differences were statistically significant(P<0.05).After treatment,EF,HMO and CI in the two groups were higher than those before treatment,and those in the study group were higher than the routine group,the differences were statistically significant(P<0.05).Conclusion Atorvastatin combined with clopidogrel in the treatment of patients with angina pectoris of coronary heart disease can effectively reduce blood lipid levels,improve hemorheology and enhance cardiac function,which is worthy of clinical promotion and application.
作者
赖艳辉
LAI Yanhui(Pingxiang NO.2 People's Hospital,Pingxiang,Jiangxi,337000,China)
出处
《当代医学》
2023年第15期170-173,共4页
Contemporary Medicine
基金
江西省卫计委资助课题(20195607)。
关键词
冠心病
血液流变学
心绞痛
血脂水平
心功能
Coronary heart disease
Hemorheology
Angina pectoris
Blood lipid level
Cardiac function
