摘要
探讨中医药治疗病态窦房结综合征(sick sinus syndrome,SSS)的方药规律,为临床辨证治疗提供参考依据。分别检索中国知网(CNKI)、万方(Wanfang)、维普(VIP)、中国生物医学文献服务系统(SinoMed)中医药治疗SSS的相关文献,提取合格文献信息并建立数据库,检索年限为建库至2023年1月31日。分别采用Lantern 5.0及Rstudio软件,对频率>3.00%的中药进行隐结构模型与关联规则分析,并结合频数描述,探讨中医药治疗SSS的用药规律。纳入中医处方192篇,涉及中药115味,累计频次1 816次。高频中药有附子、人参、甘草、黄芪、丹参等,功效以补虚药、辛温解表药和活血化瘀药为主。隐结构分析共获得13个隐变量、26个隐类、8个综合聚类模型,21个核心方剂,推测SSS常见证候有心阳气虚证、心脾阳虚证、心肾阳虚证、阳虚血瘀证、气阴两虚血瘀证、阴阳两虚证等。关联规则分析获取30条强关联规则,其中支持度最高的是人参-附子。SSS为本虚标实之证,以阳虚、气虚为本,寒、痰、瘀为标,临床治疗以温阳益气为主,随证配合活血化瘀、温里散寒、行气化痰等治法。
This study aims to mine the regularity of traditional Chinese medicine(TCM) prescriptions for sick sinus syndrome(SSS) and provide a reference for clinical syndrome differentiation and treatment.The relevant papers were retrieved from CNKI,Wanfang,VIP,and SinoMed with the time interval from inception to January 31,2023.The relevant information from qualified papers was extracted to establish a library.Lantern 5.0 and Rstudio were used to analyze the latent structure and association rules of TCMs with the frequency ≥3%,which combined with frequency descriptions,were used to explore the rules of TCM prescriptions for SSS.A total of 192 TCM prescriptions were included,involving 115 TCMs with the cumulative frequency of 1 816.High-frequency TCMs include Aconiti Lateralis Radix Praeparata,Ginseng Radix et Rhizoma,Glycyrrhizae Radix et Rhizoma,Astragali Radix,and Salviae Miltiorrhizae Radix et Rhizoma.The high-frequency medicines mainly had the effects of tonifying,releasing exterior with pungent-warm,and activating blood and resolving stasis.The analysis of the latent structure model yielded 13 hidden variables,26 hidden classes,8 comprehensive cluster models,and 21 core prescriptions.Accordingly,the common syndromes of SSS were inferred as heart-Yang Qi deficiency,heart-spleen Yang deficiency,heart-kidney Yang deficiency,Yang deficiency and blood stasis,both Qi and Yin deficiency and blood stasis,and Yin and Yang deficiency.The analysis of association rules predicted 30 strong association rules,among which Ginseng Radix et Rhizoma-Aconiti Lateralis Radix Praeparata had the highest support.SSS is a syndrome with Yang deficiency and Qi deficiency as the root causes and cold,phlegm,and stasis as the manifestations.The clinical treatment of SSS should focus on warming Yang and replenishing Qi,which should be supplemented with the therapies of activating blood and resolving stasis,warming interior and dissipating cold,or regulating Qi movement for resolving phlegm according to the patients′ syndromes.
作者
卫靖靖
于瑞
郝鹏乐
李兴渊
王新陆
乔利杰
朱明军
WEI Jing-jing;YU Rui;HAO Peng-le;LI Xing-yuan;WANG Xin-lu;QIAO Li-jie;ZHU Ming-jun(the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2023年第22期6225-6233,共9页
China Journal of Chinese Materia Medica
基金
国家自然科学基金重点项目(82030120)
国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者项目(国中医药人教函[2021]203号)
河南省中医药科学研究专项(2018JDZX009)。
关键词
病态窦房结综合征
隐结构
关联规则
用药规律
sick sinus syndrome
latent structure
association rule
prescription regularity
