摘要
目的 研究Ⅱ型糖尿病患者胰岛素抵抗与血脂代谢的关系。方法 测定109例糖尿病患者及86例正常人空腹血糖(FPG)、糖化血红蛋白(HbA_(1c))、空腹胰岛索(FINS)、体重指数(BMI)、腰臀比(WHR)及脂代谢指标,并进行相关性分析。结果 (1)109例糖尿病患者BMI、FPG、HbA_(1c)、FINS、胆固醇(CHO)、甘油三酯(TG)、极低密度脂蛋白(VLDL)、载脂蛋白B(ApoB)及胰岛素抵抗指数(HOMA-IR)明显高于正常对照组。(2)Pearson相关分析表明,HOMA-IR与BMI、腰/臀、TG、VLDL呈正相关。(3)逐步回归分析发现BMI和TG对HOMA-IR有影响。以HOMA-IR为因变量,BMI、TG为自变量,发现BMI对HOMA-IR有影响。结论 高TG是Ⅱ型糖尿病胰岛素抵抗的特点,BMI升高可作为Ⅱ型糖尿病胰岛素抵抗的独立因素。
OBJECTIVE To study the association between insulin resistance and lipid metabolism in type H diabetes mellitus(DM). METHOD Fasting plasma glucose(FPG).,HbA1c.Fasting insulin (FINS)., body mass index (BMI). waist hip ratio(WHR) and plasma lipids were determined in 109 case of type Ⅱ diabetes and 86 case of health controls. RESULTS (1)The levels of BMI.FPG,HbA1C.FINS.triglyceride(TG), cholesterol (CHO) .very low density lipoprotein(VLDL) ,apolipoproteinB(ApoB) and homeostasis model assessment-insulin resistance (HOMA-IR) in type Ⅱ DM were higher than those in the control group. (2)Pearson correlation analysis indicated that therebe existed positive correlations between HOMA - IR and BMI.WHR.TG.VLDL. (3)Stepwise regression analysis in dicated that BMI and TG were associated with HOMA - IR. And HOMA - IR was independently associated with BMI. CONCLUSIONS Type II diabetes patients with insulin resistance are characterized by high TG levels,and BMI could be regarded as independent factors for insulin resistance.
出处
《中国初级卫生保健》
2002年第11期26-27,共2页
Chinese Primary Health Care
关键词
Ⅱ型糖尿病
胰岛素抵抗
脂代谢
type Ⅱ diabetes mellitus, insulin resistance, lipid
