摘要
目的观察针药并用治疗寻常型银屑病血瘀证的临床疗效及对患者皮损程度和摄食抑制因子-1(nesfatin-1)水平的影响。方法将80例寻常型银屑病患者随机分成中药组和针药组,每组40例。中药组采用活血化瘀汤治疗,针药组在中药组治疗基础上联合火针治疗。比较两组临床疗效,观察两组治疗前、治疗4周后和治疗后中医证候积分、银屑病皮损面积及严重度指数(psoriasis area and severity index,PASI)评分以及血清干扰素-γ(interferonγ,IFN-γ)和Nesfatin-1水平的变化。结果针药组总有效率为92.5%,明显高于中药组的75.0%(P<0.05)。两组中医证候积分和PASI评分均随治疗时间延长而逐渐降低(P<0.05),组间和时点存在交互作用(P<0.05);针药组治疗4周后及治疗后中医证候积分和PASI评分均明显低于中药组(P<0.05)。治疗后,两组血清IFN-γ水平均低于治疗前(P<0.05),血清Nesfatin-1水平均高于治疗前(P<0.05);且针药组上述血清指标均明显优于中药组(P<0.05)。结论火针联合活血化瘀汤治疗血瘀证寻常型银屑病的临床疗效优于单纯活血化瘀汤治疗,可改善临床症状和皮损,且可有效调节血清IFN-γ和Nesfatin-1水平。
Objective To observe the clinical efficacy of the combination of acupuncture and Chinese medicine in the treatment of psoriasis vulgaris with blood stasis pattern and its influence on the degree of skin lesions and the level of nesfatin-1.Method A total of 80 patients with psoriasis vulgaris were randomly divided into a Chinese medicine group and an acupuncture-medicine combination group,with 40 cases in each group.The Chinese medicine group was treated with Huo Xue Hua Yu Tang,and the acupuncture-medicine combination group was treated with fire needling in addition to the treatment used in the Chinese medicine group.The clinical efficacy was compared between the two groups,and the TCM syndrome scores,psoriasis area and severity index(PASI)scores and serum interferonγ(IFN-γ)and Nesfatin-1 levels were observed before treatment,after 4 weeks of treatment and after treatment between the two groups.Result The total response rate was 92.5%in the acupuncture-medicine combination group,which was significantly higher than 75.0%in the Chinese medicine group(P<0.05).The TCM syndrome scores and PASI scores of the two groups gradually decreased with the extension of treatment time(P<0.05),and there was an interaction between the groups and time points(P<0.05).After 4 weeks of treatment and after treatment,the TCM syndrome scores and PASI scores in the acupuncture-medicine combination group were significantly lower than those in the Chinese medicine group(P<0.05).After treatment,the serum levels of IFN-γin the two groups were lower than those before treatment(P<0.05),and the serum levels of nesfatin-1 were higher than those before treatment(P<0.05).The above serum indexes in the acupuncture-medicine combination group were significantly better than those in the Chinese medicine group(P<0.05).Conclusion The clinical efficacy of fire needling combined with Huo Xue Hua Yu Tang in the treatment of psoriasis vulgaris with blood stasis pattern is better than that of Huo Xue Hua Yu Tang monotherapy,which can improve clinical symptoms and skin lesions,and effectively regulate serum IFN-γand nesfatin-1 levels.
作者
赵娜
安骏腾
王艳心
ZHAO Na;AN Junteng;WANG Yanxin(Cangzhou Hospital of Integrated Chinese medicine and Western medicine,Hebei,Cangzhou 061000,China)
出处
《上海针灸杂志》
CSCD
2023年第10期1081-1085,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
河北省中医药管理局资助项目(2022230)。
关键词
火针
针药并用
血瘀
活血化瘀汤
银屑病
寻常型
摄食抑制因子-1
干扰素-Γ
Fire needling
Acupuncture medication combined
Blood stasis
Huo Xue Hua Yu Tang
Psoriasis vulgaris
Nesfatin-1
Interferon-γ
