摘要
在离子液体均相体系中合成新型两亲性壳寡糖衍生物月桂基-琥珀酰化壳寡糖(LSCOS)。通过傅立叶红外光谱仪对LSCOS进行结构表征,并通过分子荧光分光光度计和透射电子显微镜对其表面活性及自组装行为进行研究,同时通过对回收后的离子液体进行杂质及性能研究,进一步证明离子液体的可回收利用性。结果表明:在离子液体中成功合成了LSCOS。LSCOS具有良好表面活性,临界胶束浓度较低,为1.55×10^(-4) g·mL^(-1),使其易于在水溶液中自组装形成稳定的球形纳米胶束,胶束粒径分布较窄(40~80 nm),使其可以比较稳定地存在于水溶液中。因此,在离子液体中合成的壳寡糖衍生物(LSCOS)有望发展成为功能良好的适用于疏水性药物体内运输的载体材料。同时离子液体作为壳聚糖衍生化反应的溶剂具有高效性,在经过三次回收处理后仍然具有很高的纯度,有回收重新利用的价值。
A novel water-soluble amphiphilic derivative of chitosan oligosaccharide(COS),lauryl-succinyl-COS(LS⁃COS)was synthesized in ionic liquid homogeneous system.The chemical structures of the COS derivative was characterized byFTIR.The surface activity properties and self-assembly behavior of LSCOS in aqueous solutions were studied by fluores⁃cence measurements and TEM.The results showed that LSCOS was successfully synthesized in[BMIM]Ac.LSCOS had good surface activity and the low critical micelle concentration(cmc)value was 1.55×10^(-4) g·mL^(-1).Furthermore,LSCOS could self-assemble into stable nano-micelles with well-defined spherical shape and narrow particle size distribution(40~80 nm)in aqueous solution.It indicated that LSCOS micelles have the advantage of becoming a potential drug carrier raw material in biological medicine field.At the same time,ionic liquid as the solvent of chitosan derivatization reaction has high efficiency.And the result of 1H NMR indicated that the recycled[BMIM]Ac ionic liquid had a relatively high purity,such that its reuse was feasible.
作者
刘圆圆
蒋永丰
黄燕
LIU Yuan-yuan;JIANG Yong-feng;HUANG Yan(Jiangsu Hengrui Pharmaceutical Co.Ltd.,Lianyungang 222000,China;Jiangsu Zhongjian Engineering Design and Research Institute Co.Ltd.,Jiangsu 222000,China;School of Chemistry and Chemical Engineering,Jiangsu University,Zhenjiang 212013,China)
出处
《安徽化工》
CAS
2023年第4期77-80,共4页
Anhui Chemical Industry
关键词
离子液体
壳寡糖
衍生物
自组装
胶束
ionic liquids
chitosan oligosaccharide
amphiphilic derivative
self-assembled
micelles
