摘要
目的 :探讨我国抗糖尿病药物不良反应(ADR)发生的一般规律及有关特点 ,为临床用药提供资料。方法 :对个人呈报的ADR报告 ,参照国家卫生部ADR监测中心指定的原则列入分析文献源 ,ADR按世界卫生组织 (WHO)国际药品监测合作中心的药物ADR分类方法分类 ,我们收集了国内 4 2a文献源抗糖尿病药物的ADR资料 ,并进行文献计量学分析。结果 :抗糖尿病药物ADR的发生男性、女性数量相当 ;从年龄结构来看 ,ADR发生集中于 4 5～ 74a年龄段。抗糖尿病药物的ADR是以代谢和营养障碍、神经系统损害、精神紊乱、胃肠系统损害为主 ,其中除胃肠系统损害主要由阿卡波糖引起外 ,其余以磺酰脲类抗糖尿病药物占绝大多数 ;抗糖尿病药物的ADR绝大多数预后良好 ,但亦有相当数量的ADR留有后遗症甚至死亡 ,其中以格列本脲和苯乙双胍引起的ADR预后较差。结论 :抗糖尿病药物ADR涉及系统广泛 ,有些后果严重 。
AIM: To explore the general law and characteristic of the adverse drug reaction (ADR) of antidiabetic agents, providing the information to clinical drug utilization. METHODS: A metrological analysis was conducted on data of ADR of antidiabetic agents in documents within 42 a. RESULTS: The amounts of ADR of antidiabetic agents were equal in men and women, and mainly aged from 45 a to 74 a. The major ADR was metabolism and nutrition barriers, nervous system injured, mental disorder and stomach intestinal system injured. Except acarbose causing stomach and intestinal system injured, the rest ADR was mainly caused by sulphonylureas. The most of prognosis of ADR of antidiabetic agents were good, but also quite a number of them left sequela or death. CONCLUSION: The ADR of antidiabetic agents is comprehensive, some of them are severe. It is worth attaching clinical importance to.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2002年第12期753-758,共6页
Chinese Journal of New Drugs and Clinical Remedies
关键词
降血糖药
文献计量学
糖尿病
糖尿病
非胰岛素依赖型
药物不良反应
hypoglycemic agents
bibliometrics
diabetes mellitus
diabetes mellitus, non-insulin-dependent
adverse drug reaction
