摘要
目的了解苯妥英钠不良反应(ADR)发生的一般规律及特点。方法收集国内12年间关于苯妥英钠ADR的文献源并加以统计分析。结果苯妥英钠ADR的发生男性多于女性,且集中于10～40岁年龄段,以中枢神经系统(CNS)、血液系统和皮肤的损害为主,预后较好,有95.77%的患者痊愈或好转,4.23%的患者死亡。结论临床治疗中应重视苯妥英钠所致ADR,加强血药浓度监测,确保用药的合理性和安全性。
Objective To investigate the rules and characteristics of adverse drug reactions （ADR） of phenytion sodium, Methods The data of ADR of phenytion sodium on literatures within 12 years were analyed. Results The patients aged from 10 to 40 and male were more than female. Nervous system was the most frequent, the following were blood system and skin injury. The outcome of ADR was well, 95.77% of the patients could cure or improve. But also 4. 23% of the patients were dead. Conclusion Great attention should be paid to the ADR of phenytion sodium in clinic and the clinical monitoring should be enhanced. Be sure safe and rational in clinical phenytion sodium application.
出处
《中国药业》
CAS
2007年第19期38-39,共2页
China Pharmaceuticals
关键词
苯妥英钠
不良反应
文献分析
phenytion sodium
adverse drug reaction
literature analysis
