摘要
目的 分析康柏西普联合眼底激光治疗糖尿病视网膜病变(DR)合并视网膜静脉阻塞(RVO)黄斑水肿的效果。方法 97例DR合并RVO黄斑水肿患者,按照随机数字表法分为对照组(48例)与研究组(49例)。对照组接受眼底激光治疗,研究组接受康柏西普联合眼底激光治疗。比较两组患者症状改善与消退时间、黄斑中心凹厚度(CMT)、最佳矫正视力(BCVA)、低视力生活质量量表(CLVQOL)评分及并发症发生情况。结果 研究组黄斑水肿改善时间(4.30±0.36)周、眼底出血吸收时间(2.35±0.25)周、渗出吸收时间(10.25±0.93)周均短于对照组的(5.56±0.40)、(3.20±0.30)、(12.20±1.25)周,差异有统计学意义(P<0.05)。治疗后4周,研究组BCVA(0.82±0.15)高于对照组的(0.55±0.12), CMT(245.65±22.50)μm低于对照组的(273.38±28.44)μm,差异有统计学意义(P<0.05)。治疗后3个月,研究组CLVQOL评分(80.35±4.52)分高于对照组的(72.65±5.00)分,差异有统计学意义(P<0.05)。两组并发症发生率比较差异无统计学意义(P>0.05)。结论 康柏西普联合眼底激光治疗DR合并RVO黄斑水肿可以有效改善患者的黄斑厚度与视力水平,促进症状快速改善与消退,保障其生活质量,适于临床推广。
Objective To analyze the effect of Conbercept combined with fundus laser in the treatment of macular edema caused by diabetes retinopathy(DR)with retinal vein occlusion(RVO).Methods A total of 97 patients with macular edema caused by DR with RVO were divided into control group(48 cases)and study group(49 cases)according to random numerical table.The control group received fundus laser treatment,and the study group received Compacept combined fundus laser treatment.Both groups were compared in terms of time of symptom improvement and regression,the central macular thickness(CMT),the best corrected visual acuity(BCVA),the Chinese version of the low vision quality of life questionnaire(CLVQOL)scores of patients with low vision,and the complications.Results In the study group,the improvement time of macular edema was(4.30±0.36)weeks,the absorption time of fundus hemorrhage was(2.35±0.25)weeks,and the exudation absorption time was(10.25±0.93)weeks,which were shorter than those of(5.56±0.40),(3.20±0.30)and(12.20±1.25)weeks in the control group,and the differences were statistically significant(P<0.05).At 4 weeks after treatment,BCVA of(0.82±0.15)in the study group was higher than that of(0.55±0.12)in the control group,and CMT of(245.65±22.50)μm was lower than that of(273.38±28.44)μm in the control group.The differences were statistically significant(P<0.05).At 3 months after treatment,the CLVQOL score of the study group was(80.35±4.52)points,which was higher than that of(72.65±5.00)points in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P>0.05).Conclusion Conbercept combined with fundus laser can effectively improve the macular thickness and visual acuity of patients with macular edema caused by DR with RVO,promote the rapid improvement and regression of symptoms,and ensure their quality of life,which is suitable for clinical promotion.
作者
吕春英
李慧
LYU Chun-ying;LI Hui(Department of Ophthalmology,Heze Municipal Hospital,Heze 274000,China)
出处
《中国实用医药》
2023年第17期14-17,共4页
China Practical Medicine
