摘要
目的:探讨超声引导下腹横肌平面(TAP)阻滞复合全身麻醉对腹部手术患者炎症因子及免疫功能的影响。方法:回顾性分析2021年10月-2022年10月潮州市潮安区人民医院收治的106例腹部手术患者的资料。根据不同麻醉方法将其分为对照组(n=44)与联合组(n=62)。对照组给予全身麻醉,联合组在对照组的基础上给予超声引导下TAP阻滞。比较两组围手术期指标,术前、术后24 h炎症因子及免疫功能。结果:联合组苏醒时间、拔管时间均早于对照组,丙泊酚用量及舒芬太尼用量均少于对照组,差异有统计学意义(P<0.05)。术后24 h,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平均较术前升高,联合组TNF-α、CRP、IL-1、IL-6水平均低于对照组,差异有统计学意义(P<0.05)。术后24 h,两组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均较术前降低,CD8^(+)高于术前,联合组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于对照组,CD8^(+)低于对照组,差异有统计学意义(P<0.05)。结论:超声引导下TAP阻滞复合全身麻醉可有效缩短腹部手术患者拔管时间,促进康复,降低术后炎症因子水平及改善免疫功能。
Objective:To explore the effect of transversus abdominis plane(TAP)block under ultrasound-guided combined with general anesthesia on inflammatory factors and immune function of patients undergoing abdominal surgery.Method:The data of 106 patients undergoing abdominal surgery treated in Chao’an District People's Hospital of Chaozhou City from October 2021 to October 2022 were retrospectively analyzed.According to different anesthesia methods,they were divided into control group(n=44)and combination group(n=62).The control group was given general anesthesia,and the combination group was given TAP block under ultrasound-guided based on the control group.Perioperative indexes,inflammatory factors and immune function before and 24 h after surgery were compared between the two groups.Result:The recovery time and extubation time of combination group were earlier than those of control group,and the dosage of Propofol and Sufentanil were less than those of control group,the differences were statistically significant(P<0.05).After 24 h of surgery,the levels of tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),interleukin-6(IL-6)and C-reactive protein(CRP)in the two groups were higher than those before surgery,and the levels of TNF-α,CRP,IL-1 and IL-6 in combination group were lower than those in control group,the differences were statistically significant(P<0.05).After 24 h of surgery,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in both groups were lower than those before surgery,and CD8^(+)was higher than that before surgery,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the combination group were higher than those in the control group,and CD8^(+)was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion:TAP block under ultrasound-guided combined with general anesthesia can effectively shorten the extubation time of abdominal surgery patients,promote recovery,reduce the level of postoperative inflammatory factors,improve immune function.
作者
黄树彬
幸丹
蔡小燕
陈泽莲
HUANG Shubin;XING Dan;CAI Xiaoyan;CHEN Zelian(Chao’an District People's Hospital of Chaozhou City,Chaozhou 515638,China;不详)
出处
《中外医学研究》
2023年第22期37-40,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
2021潮州市科技计划项目(2021ZC46)。
关键词
超声引导下腹横肌平面阻滞
全身麻醉
腹部手术
炎症因子
免疫功能
Transversus abdominis plane block under ultrasound-guided
General anesthesia
Abdominal surgery
Inflammatory factors
Immune function
