摘要
生物活性玻璃(BG)具有优良的生物性能且无细胞毒性,可促进骨和软组织再生,近年来已广泛应用于人工骨支架的制备。但由于玻璃材料多存在脆性大、机械强度差、易团聚且结构不可控等缺点,使其在各领域中的应用受到限制。对此,当前大多数研究主要聚焦于采用冷冻干燥法、溶胶凝胶法等将其与有机或无机材料进行混合,以改善BG的机械性能及其脆性等,进而增加其临床应用、拓展其应用领域。本文通过介绍BG与天然有机材料、金属材料、非金属材料结合形成复合材料,及进一步开发其作为支架、注射填充剂、膜、水凝胶和涂层等产品的方式,展现了当前领域内制备BG复合材料的最新技术和应用前景。研究分析表明,BG的加入改善了原有材料的机械性能及其生物活性和再生潜力,拓宽了BG在骨组织工程领域的应用。本文通过回顾近年来BG在骨再生研究方面的研究进展,展现了BG在新材料研发领域的潜力,以期为今后的相关研究提供参考借鉴。
Bioactive glass(BG)has been widely used in the preparation of artificial bone scaffolds due to its excellent biological properties and non-cytotoxicity,which can promote bone and soft tissue regeneration.However,due to the brittleness,poor mechanical strength,easy agglomeration and uncontrollable structure of glass material,its application in various fields is limited.In this regard,most current researches mainly focus on mixing BG with organic or inorganic materials by freeze-drying method,sol-gel method,etc.,to improve its mechanical properties and brittleness,so as to increase its clinical application and expand its application field.This review introduces the combination of BG with natural organic materials,metallic materials and non-metallic materials,and demonstrates the latest technology and future prospects of BG composite materials through the development of scaffolds,injectable fillers,membranes,hydrogels and coatings.The previous studies show that the addition of BG improves the mechanical properties,biological activity and regeneration potential of the composites,and broadens the application of BG in the field of bone tissue engineering.By reviewing the recent BG researches on bone regeneration,the research potential of new materials is demonstrated,in order to provide a reference for future related research.
作者
彭雨
兰梁
穆君宇
侯沙(综述)
程丽佳(审校)
PENG Yu;LAN Liang;MU Junyu;HOU Sha;CHENG Lijia(Basic Medical School,Chengdu University,Chengdu 610106,P.R.China)
出处
《生物医学工程学杂志》
EI
CAS
北大核心
2023年第4期805-811,共7页
Journal of Biomedical Engineering
基金
国家自然科学基金(81803561)
教育部产学合作协同育人项目(202101011010)
成都市医学科研课题(2021043)
成都大学CC国家众创空间2021年度创新创业教育专项课题(ccyg202101008)
四川省省级大学生创新训练计划项目(S202111079095)。
关键词
生物活性玻璃
复合材料
无机材料
有机材料
骨组织工程
Bioactive glass
Composite materials
Inorganic materials
Organic materials
Bone tissue engineering
