摘要
用硼酸盐生物玻璃/壳聚糖复合材料制备替考拉宁缓释载体,用高效液相色谱仪检测该缓释系统在磷酸盐缓冲液中的抗生素释放浓度,并通过Peppas方程拟合研究其释放动力学,观察在缓释过程中溶液pH值和载体材料抗压强度的变化。用扫描电镜和X射线衍射对复合材料的体外生物活性和降解性能进行表征。结果表明:硼酸盐生物玻璃/壳聚糖复合材料可以成为一种长期有效的替考拉宁载体。药物的释放机制符合Fickian扩散定律。此外,由该复合材料制备的载体可以提供足够的抗压强度用于负重部位骨缺损修复,并且在药物释放过程中逐渐转化为羟基磷灰石,表现出优良的生物活性。
A composite material composed of melt-derived borate bioactive glass and chitosan（BG/CS） was developed as a carrier for sustained release of antibiotics.The in vitro release kinetics of teicoplanin from the BG/CS after immersion in phosphate buffered saline（PBS） was determined using high performance liquid chormatography and modeled using the Peppas equations.The pH value changes of PBS and the compressive strength of the composite carrier during the release process were measured.And the in vitro bioactivity and biodegradability of the BG/CS were also characterized using scanning electron microscope and X-ray diffraction techniques.The results show that the BG/CS carrier can provide a sustained release of teicoplanin,which is controlled by Fickian diffusion.An adequate mechanical strength of the composite carrier can be obtained to serve a load-bearing function.Meanwhile,the surface of the composite is converted to hydroxyapatite（HA） with the degradation of materials,indicating the favorable osteogenic activity in vivo.
出处
《硅酸盐学报》
EI
CAS
CSCD
北大核心
2010年第7期1303-1309,共7页
Journal of The Chinese Ceramic Society
基金
上海市科委纳米专项(0952nm03400)
上海市科委重点项目(084419005000)资助项目
