摘要
抑郁症是目前最常见的一种心理疾病,但其发病机制复杂且尚未完全明确。越来越多的证据表明神经炎症在抑郁症的发病机制中起重要作用,核苷酸结合寡聚化结构域样受体蛋白3(nucleotide-binding oligomerization domain-like receptor protein 3,NLRP3)是神经炎症的关键位点。并且NLRP3炎症小体还可以介导细胞焦亡。因此,本文通过对NLRP3炎症小体展开研究,探究其激活方式、组成、信号通路调控机制及其相关抑制剂,为抑郁症的诊疗和抗抑郁症药物的研发工作提供新的思路及依据。
Depression is the most common psychological disease at present,but its pathogenesis is complex and has not been fully defined.More and more evidence shows that neuroinflammation plays an important role in the pathogenesis of depression.Nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3) is the key site of neuroinflammation.Moreover,NLRP3 inflammasome can also mediate cell apoptosis.Therefore,through reviewing the development of research on NLRP3 inflammasome,this paper explores its activation mode,composition,signal pathway regulation mechanism and related inhibitors,so as to provide new ideas and basis for the diagnosis and treatment of depression and the research and development of antidepressants.
作者
郭馨蕾
高明奇
秦瑜
GUO Xin-lei;GAO Ming-qi;QIN Yu(Department of Clinical Pharmacology,School of Pharmacy,China Medical University,Shenyang 110000,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2023年第14期1438-1445,共8页
Chinese Journal of New Drugs
基金
辽宁省教育厅科研项目(LJKZ0778)。
