摘要
目的 探讨依诺肝素钠联合硝苯地平对妊娠高血压患者子宫动脉血流及母婴结局的影响。方法选取2020年1月至2021年8月平阳县人民医院就诊的妊娠高血压患者为研究对象,根据患者实际用药情况分为观察组和对照组。两组均给予常规治疗,对照组患者加用硝苯地平,观察组患者在对照组用药基础上加用依诺肝素钠。比较两组患者治疗前后的血压、子宫动脉血流血栓弹力图参数、抗氧化指标、内皮损伤指标及母婴结局。结果 共纳入100例患者,观察组48例,对照组52例。治疗后,两组患者收缩压和舒张压水平较治疗前显著降低,且观察组收缩压和舒张压水平显著低于对照组,差异均有统计学意义(P<0.05)。两组患者的凝血反应时间、凝固角、最大振幅、超氧化物歧化酶、总抗氧化能力、一氧化氮和前列腺素E水平均较治疗前显著升高,且观察组各指标显著高于对照组(P<0.05);两组患者的血凝块形成时间、过氧化物、丙二醛、内皮素和血管细胞黏附分子-1水平均较治疗前显著降低,且观察组各指标显著低于对照组,差异有统计学意义(P<0.05)。观察组新生儿窒息和产妇早产、剖宫产及产后出血发生率均低于对照组,差异有统计学意义(P<0.05)。结论 依诺肝素钠联合硝苯地平治疗妊娠高血压可显著降低患者血压,稳定子宫动脉血流,增强机体抗氧化功能,改善内皮功能及母婴结局。
Objective To investigate the effect of enoxaparin sodium combined with nifedipine on uterine arterial blood flow and maternal and infant outcomes in patients with gestational hypertension.Methods The patients with gestational hypertension admitted in the People's Hospital of Pingyang from January 2020 to August 2021 were selected as research subjects,and they were divided into the observation group and the control group according to the specific medication method.Both groups were given routine treatment,and the control group was given nifedipine,and the observation group was given enoxaparin sodium on the basis of the control group.Blood pressure,uterine artery blood flow thromboelastogram parameters,antioxidant indexes,endothelial injury indexes and maternal and infant outcomes were compared between the two groups before and after treatment.Results A total of 100 patients were included,with 52 in the observation group and 48in the control group.After treatment,the systolic blood pressure and the diastolic blood pressure levels in the two groups were significantly reduced compared to those before treatment,and the systolic blood pressure and the diastolic blood pressure levels in the observation group were significantly lower than those in the control group with statistical differences(P<0.05).The clotting reaction time,angle of solidification,maximal amplitude superoxide dismutase,total antioxidant capacity,nitric oxide and prostaglandin E in the two groups were significantly higher than those before treatment,and the indicators in the observation group were significantly higher than those in the control group(P<0.05).The blood clot formation time,peroxide,malondialdehyde,endothelin and vascular cell adhesion molecule-1 in the two groups were significantly lower than those before treatment,and the indicators in the observation group were significantly lower than those in the control group with a statistically significant differences(P<0.05).The incidence of neonatal asphyxia,premature delivery,cesarean section and postpartum hemorrhage in the observation group were lower than those in the control group with statistical differences(P<0.05).Conclusion Enoxaparin sodium combined with nifedipine in the treatment of hypertensive patients during pregnancy can significantly reduce blood pressure,stabilize uterine artery blood flow,increase antioxidant capacity and improve endothelial function and maternal and infant outcomes.
作者
洪苏秒
张劻锋
陈海雁
HONG Su-miao;ZHANG Kuang-feng;CHEN Hai-yan(Department of Obstetrical,the People's Hospital of Pingyang,Zhejiang Wenzhou 325400,China;Department of Operating Room,the People's Hospital of Pingyang,Zhejiang Wenzhou 325400,China;Department of Emergency,the People's Hospital of Pingyang,Zhejiang Wenzhou 325400,China)
出处
《临床药物治疗杂志》
2023年第7期46-51,共6页
Clinical Medication Journal
关键词
依诺肝素钠
硝苯地平
妊娠高血压
子宫动脉血流
母婴结局
enoxaparin sodium
nifedipine
gestational hypertension
uterine arterial blood flow
maternal and infant outcomes
