摘要
目的分析地特胰岛素治疗妊娠期糖尿病的效果及对妊娠结局的影响。方法按照降糖方案的差异将2020年1月至12月收治的80例妊娠期糖尿病孕妇分为观察组(40例,地特胰岛素治疗)和常规组(40例,精蛋白锌重组人胰岛素注射液治疗)。比较两组的治疗效果。结果治疗3个月后,观察组的空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、视黄醇结合蛋白4(RBP4)、转化生长因子β_(1)(TGF-β_(1))及总胆红素(TBIL)水平均显著低于常规组,差异具有统计学意义(P<0.05)。治疗1、3个月后,观察组的平均血糖波动幅度(MAGE)、日间血糖平均绝对差(MODD)均显著低于常规组,差异具有统计学意义(P<0.05)。观察组的低血糖、早产及巨大儿发生率均显著低于常规组,差异具有统计学意义(P<0.05)。结论地特胰岛素治疗妊娠期糖尿病可有效改善妊娠结局,取得理想效果。
Objective To analyze the effect of insulin detemir in the treatment of gestational diabetes mellitus and its influence on pregnancy outcome.Methods A total of 80 pregnant women with gestational diabetes mellitus admitted from January to December 2020 were divided into observation group(40 cases,insulin detemir treatment)and conventional group(40 cases,protamine zinc recombinant human insulin injection treatment)according to the difference of hypoglycemic regimen.The therapeutic effects of the two groups were compared.Results After 3 months of treatment,the levels of fasting plasma glucose(FPG),2 h postprandial blood glucose(2 h PG),glycated hemoglobin(HbA1c),retinal binding protein 4(RBP4),transforming growth factor-β_(1)(TGF-β_(1))and total bilirubin(TBIL)in the observation group were significantly lower than those in the conventional group,and the differences were statistically significant(P<0.05).After 1 and 3 months of treatment,the mean amplitude of glycemic excuisions(MAGE)and mean of daily differences(MODD)in the observation group were significantly lower than those in the conventional group,and the differences were statistically significant(P<0.05).The incidence of hypoglycemia,premature delivery and macrosomia in the observation group were significantly lower than those in the conventional group,and the differences were statistically significant(P<0.05).Conclusion Insulin detemir in the treatment of gestational diabetes mellitus can effectively improve the pregnancy outcome and achieve the ideal effect.
作者
陈夏
曾广霞
CHEN Xia;ZENG Guangxia(Ankang Hospital of Traditional Chinese Medicine,Ankang 725000;Ankang Central Hospital,Ankang725000,China)
出处
《临床医学研究与实践》
2023年第22期137-140,共4页
Clinical Research and Practice
关键词
妊娠期糖尿病
地特胰岛素
精蛋白锌重组人胰岛素注射液
妊娠结局
gestational diabetes mellitus
insulin detemir
protamine zinc recombinant human insulin injection
pregnancy outcome
