摘要
肺纤维化属于间质性肺疾病的一种,作为呼吸系统疑难疾病之一,预后非常差,其发病机制尚未完全明确。IL-1β作为一种细胞炎性因子,可参与调节各种损伤状态下炎症反应发生和后期组织修复。ILC2可产生Th2相关细胞因子,在组织内稳态和纤维化中起到重要作用。TGF-β1是促纤维化因子,参与了肺纤维化的发生。近年来的研究发现,IL-1β、ILC2及TGF-β1均与肺纤维化疾病的形成过程有关。本文就近年来IL-1β、ILC2及TGF-β1调控机制的研究及其在肺纤维化疾病中的作用做一综述,为肺纤维化治疗新靶点的研发提供依据。
Pulmonary fibrosis is a common type of interstitial lung disease,and as one of the difficult respiratory diseases,its prognosis is very poor,and its pathogenesis has not yet fully understood.IL-1β,as a cellular inflammatory factor,is involved in regulating inflammatory and tissue repair responses to injury.ILC2 can produce Th2 related cytokines and play an important role in tissue homeostasis and fibrosis.TGF-β1 is a profibrotic factor that participates in the occurrence of pulmonary fibrosis.Recent studies have found that IL-1β,ILC2 and TGF-β1 are related to the formation process of pulmonary fibrosis disease.This article reviews the regulatory mechanisms of IL-1,ILC2 and TGF-βand their roles in pulmonary fibrosis,providing a basis for the development of new therapeutic targets for pulmonary fibrosis.
作者
杨胜男
何巍
YANG Shengnan;HE Wei(Postgraduate of Grade 2020,Shenyang Medical College,Shenyang 110034,China;Department of Respiratory and Critical Illness Medicine,The Central Hospital Affiliated to Shenyang Medical College)
出处
《沈阳医学院学报》
2023年第4期405-408,422,共5页
Journal of Shenyang Medical College
