摘要
目的探讨泽茵丸联合常规西药治疗湿浊阻滞、瘀血内结型非酒精性脂肪性肝病(NAFLD)的效果。方法选取2020年1月至2021年12月陕西省中医医院肝病科收治的86例湿浊阻滞、瘀血内结型NAFLD患者为研究对象,按照随机数字表法将其分为对照组与观察组,各43例。对照组采用常规西药治疗,观察组在对照组基础上加泽茵丸治疗。比较两组的临床效果。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的超氧化物歧化酶(SOD)水平高于对照组,丙二醛(MDA)、乳酸脱氢酶(LDH)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的脂多糖结合蛋白(LBP)、瘦素(LEP)水平低于对照组,脂联素(ADPN)水平高于对照组,差异具有统计学意义(P<0.05)。结论泽茵丸联合常规西药治疗湿浊阻滞、瘀血内结型NAFLD的效果满意,可调节SOD、MDA、LDH、LBP、LEP、ADPN水平,值得推广。
Objective To investigate the effect of Zeyin pill combined with conventional western medicine in the treatment of nonalcoholic fatty liver disease(NAFLD)of damp turbidity block and blood stasis knot type.Methods From January 2020 to December 2021,86 patients with NAFLD of damp turbidity block and blood stasis knot type admitted in the hepatology department of Shaanxi Provincial Hospital of Chinese Medicine were selected as the research objects.According to random number table method,the patients were divided into control group and observation group,with 43 cases in each group.The control group was treated with conventional western medicine,and the observation group was treated with Zeyin pill on the basis of the control group.The clinical effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the level of superoxide dismutase(SOD)in the observation group was higher than that in the control group,while the levels of malondialdehyde(MDA)and lactate dehydrogenase(LDH)were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of lipopolysaccharide binding protein(LBP)and leptin(LEP)in the observation group were lower than those in the control group,while the level of adiponectin(ADPN)was higher than that in the control group,and the differences were statistically significant(P<0.05).Conclusion Zeyin pill combined with conventional western medicine in the treatment of NAFLD of damp turbidity block and blood stasis knot type has satisfactory effect,it can regulate the levels of SOD,MDA,LDH,LBP,LEP and ADPN,which is worthy of promotion.
作者
刘皎皎
李粉萍
杨跃青
何瑾瑜
曹雪艳
薛敬东
叶苗青
LIU Jiaojiao;LI Fenping;YANG Yueqing;HE Jinyu;CAO Xueyan;XUE Jingdong;YE Miaoqing(Shaanxi Provincial Hospital of Chinese Medicine,Xi'an 710003,China)
出处
《临床医学研究与实践》
2023年第18期107-110,共4页
Clinical Research and Practice
基金
陕西省中医药管理局中医药科研项目(No.2021-ZZ-JC035)
陕西省中医医院院级科研课题(No.2020-02)。
关键词
泽茵丸
湿浊阻滞、瘀血内结型
非酒精性脂肪性肝病
脂多糖结合蛋白
瘦素
脂联素
Zeyin pill
damp turbidity block and blood stasis knot type
nonalcoholic fatty liver disease
lipopolysaccharide binding protein
leptin
adiponectin
