摘要
目的 探究新辅助化疗联合腹腔镜D2根治术在局部进展期胃癌患者中的应用效果。方法 选取2018年1月至2020年1月在我院接受治疗的160例局部进展期胃癌患者为研究对象,根据治疗方案的不同将其分为对照组和观察组,各80例。对照组给予腹腔镜D2根治术治疗,观察组给予新辅助化疗联合腹腔镜D2根治术治疗。比较两组的肿瘤复发率、肿瘤转移率、功能状态、营养状况、肿瘤标志物水平及生活质量。结果术后6个月、1年,观察组的肿瘤复发率低于对照组(P<0.05);术后1年,观察组的肿瘤转移率低于对照组(P<0.05);术后6个月、1年,观察组的功能状态及营养状况均优于对照组(P<0.05)。术后6个月,观察组的癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原199(CA199)、糖类抗原242(CA242)及糖类抗原724(CA724)水平均低于对照组(P<0.05)。术后1年,观察组的功能领域、总体健康状况评分高于对照组,症状领域评分低于对照组(P<0.05)。结论 新辅助化疗联合腹腔镜D2根治术在局部进展期胃癌中的应用效果显著,能有效降低患者的肿瘤复发率和肿瘤转移率,降低肿瘤标志物水平,提高患者的生活质量。
Objective To explore the application effect of neoadjuvant chemotherapy combined with laparoscopic D2 radical gastrectomy in patients with locally advanced gastric cancer.Methods A total of 160 patients with locally advanced gastric cancer who were treated in our hospital from January 2018 to January 2020 were selected as the research objects.The patients were divided into control group and observation group according to different treatment plans,with 80 cases in each group.The control group was treated with laparoscopic D2 radical gastrectomy,and the observation group was treated with neoadjuvant chemotherapy combined with laparoscopic D2 radical gastrectomy.The tumor recurrence rate,tumor metastasis rate,functional status,nutritional status,tumor markers levels and quality of life were compared between the two groups.Results At 6 months and 1 year after operation,the tumor recurrence rate of the observation group was lower than that of the control group(P<0.05);one year after operation,the tumor metastasis rate of the observation group was lower than that of the control group(P<0.05);at 6 months and 1 year after operation,the functional status and nutritional status of the observation group were better than those of the control group(P<0.05).At 6 months after operation,the levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125),carbohydrate antigen 199(CA199),carbohydrate antigen 242(CA242)and carbohydrate antigen 724(CA724)in the observation group were lower than those in the control group(P<0.05).One year after operation,the scores of function field and overall health status score of the observation group were higher than those of the control group,and the symptom field score was lower than that of the control group(P<0.05).Conclusion Neoadjuvant chemotherapy combined with laparoscopic D2 radical gastrectomy in patients with locally advanced gastric cancer has good application effect,which can effectively reduce the tumor recurrence rate and tumor metastasis rate of patients,reduce the levels of tumor markers and improve the quality of life of patients.
作者
向荣
杨晓锋
XIANG Rong;YANG Xiaofeng(Hanzhong Hospital of TCM,Hanzhong 723102;Xianyang Maternal and Child Health Care Hospital,Xianyang 712000,China)
出处
《临床医学研究与实践》
2023年第17期45-48,共4页
Clinical Research and Practice
关键词
新辅助化疗
腹腔镜D2根治术
局部进展期胃癌
neoadjuvant chemotherapy
laparoscopic D2 radical gastrectomy
locally advanced gastric cancer
