摘要
目的 本研究探讨欧米伽-3多不饱和脂肪酸(n-3 polyunsaturated fatty acids,n-3 PUFA)对于老年重度抑郁患者的认知功能的影响。方法 这是一项为期8周的随机对照试验,将73例老年重度抑郁患者随机数字表法分配到1.2g/日的n-3 PUFA鱼油组(包含720mg二十碳五烯酸(Eicosapentaenoic Acid,EPA)和480mg二十二碳六烯酸(Docosahexaenoic Acid,DHA))和安慰剂组,两组患者都是在每天接受度洛西汀60mg治疗的基础上进行干预的。使用17项汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)、连线测试A(Trail Making Test A,TMT-A)、数字符号转化测验(Digit Symbol Substitution Test,DSST)及数字广度测验(Digit Span Test,DST)对患者在T0(干预前)、T1(2周末)、T2(4周末)、T3(6周末)、T4(8周末)进行为期8周的病情及认知功能动态评估。在T0及T4期采集患者血样,用气相色谱仪法分析血浆EPA及DHA含量。结果 8周后,鱼油组患者血浆EPA含量(1.12±0.34)%和DHA含量(1.73±0.29)%均明显高于安慰剂组,均P<0.05。在T3、T4期鱼油组HAMD评分及DST评分均低于安慰剂组,有统计学差异(P<0.05)。而在TMT-A及DSST测验中两组比较没有统计学意义(P>0.05)。结论 本实验结果提示补充欧米伽-3多不饱和脂肪酸胶囊可改善老年重度抑郁患者的抑郁症状及瞬时记忆,但更需要进一步的大样本量、更长时间随访以及更明确的DHA和EPA含量研究明确结论。
Objectivee This study was aimed to explore the impact of fish oil(n-3 PUFAs)on cognitive performance in Elderly Major Depressive Disorder.Methods This is an 8-week randomized controlled trial that randomly assigned 73 elderly patients with major depression to a 1.2g/day n-3PUFA fish oil group(containing 720mgEPA and 480mg-DHA)and a placebo group.The intervention was based on daily treatment with duloxetine 60 mg.Hamilton Depression scale(HAMD),Trail Making Test A(TMT-A),Digital Symbol Substitution Test(DSST)and Digit Span Test(DST)were used to evaluate the patient's condition and cognitive function for 8 weeks at TO(before intervention),T1(week 2),T2(week 4),T3(week 6)and T4(week 8).The blood samples of the patients were collected at TO and T4,and the contents of plasma EPA and DHA were analyzed by meteorological chromatograph.Results After 8 weeks,the levels of plasma EPA and DHA in fish oil group were significantly higher than those in placebo group(P<0.05).The scores of HAMD and DST in T3 and T4 fish oil group were significantly lower than those in placebo group(P<0.05).However,there was no significant difference between the two groups in TMT-A and DSST test(P>0.05).Conclusion In this 8 weeks Double-Blind Randomized Controlled Trial,we observed n-3 PUFAs can improve depressive symptoms and cognitive function in the elderly with Major Depressive Disorder.For the rigor of the conclusion,further studies should be conducted on different fish oil dosages,longer follow-up periods and larger sample sizes.
作者
王潇潇
曲春晖
孙辰辉
孙祥虹
王圣海
孙平
WANG Xiaoxiao;QU Chunhui;SUN Chenhui(Qingdao University,Qingdao 266000,China)
出处
《国际精神病学杂志》
2023年第2期253-257,264,共6页
Journal Of International Psychiatry
基金
山东省医药卫生科技发展计划项目(编号:2017ws748)。
关键词
欧米伽-3脂肪酸
老年
重度抑郁
认知功能
In-3 PUFAs
Fish oil
The Elderly
Major Depressive Disorder
Cognitive function
