摘要
目的 探讨小而密低密度脂蛋白胆固醇(small dense low-density lipoprotein cholesterol, sdLDL-C)与高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-C)的比值与颈动脉内膜中层厚度(carotid intima-media thickness, CIMT)的关系。方法 收集2016年3月至2017年3月航天中心医院体检人群1 350例数据,根据颈动脉B超结果分为两组:颈动脉内膜中层厚度正常组(CIMT<1mm)985例(男性508例,女性477例);颈动脉内膜中层厚度异常组(CIMT≥1mm)365例(男性273例,女性92例)。采用多元线性回归,Logistic回归和限制性立方样条回归模型评估sdLDL-C/HDL-C与颈动脉内膜中层厚度的关系。结果 随着sdLDL-C/HDL-C的增加,CIMT厚度也逐渐的增大;二元Logistic回归分析,sdLDL-C/HDL-C以Q1为参照,Q4经多变量调整后异常CIMT的OR=3.72(95%CI1.86~7.41)。限制性立方样条回归显示,sdLDL-C/HDL-C与异常CIMT(P<0.001)呈线性相关。此外,在正常LDL-C(low-density lipoprotein cholesterol, LDL-C)水平的亚样本人群中(n=991),sdLDL-C/HDL-C与CIMT相关性仍然显著。结论 在体检人群中,sdLDL-C/HDL-C升高与CIMT呈正相关,并且在正常LDL-C水平的人群中,两者依然呈正相关。sdLDL-C/HDL-C是预测颈动脉厚度较好的指标。
Objective To investigate the relationship between the ratio of small dense low-density lipoprotein cholesterol and high-density lipoprotein cholesterol and carotid intima-media thickness.Methods From March,2016 to March,2017,1,350 people underwent physical examinations were enrolled in aerospace center hospital.According to the results of ultrasonography,these subjects were divided into two groups:985 patients(508 males and 477 females)with normal carotid intima-media thickness(CIMT<1mm)and 365 patients(273 males and 92 females)with abnormal carotid intima-media thickness(CIMT≥1mm).Multiple linear regression,logistic regression and restricted cubic spline regression models were used to evaluate the relationship between sdLDL-C/HDL-C and carotid intima-media thickness.Results With the increase of sdLDL-C/HDL-C quartile level,CIMT level also increased gradually.Binary logistic regression analysis showed that the Q1 of sdLDL-C/HDL-C was used as the reference,and the OR of abnormal CIMT in the Q4 after multivariate adjustment was 3.72(95%CI 1.86-7.41).Restricted cubic spline regression showed that sdLDL-C/HDL-C was linearly correlated with abnormal CIMT(P<0.001).In addition,in the subsample population with normal LDLC level(n=991),the correlation between sdLDL-C/HDL-C and CIMT was remaining significant.Conclusion The increase of sdLDL-C/HDL-C is positively correlated with CIMT in the physical examination population,and it is remaining positively correlated with the normal LDL-C level in the population.sdLDL-C/HDL-C is a promising predictor of carotid artery thickness.
作者
马福存
柏明见
王兵
梁国威
李秀锋
MA Fucun;BAI Mingjian;WANG Bing;LIANG Guowei;LI Xiufeng(The Department of Clinical Laboratory Medicine,Aerospace Center Hospital,Beijing 100049,China)
出处
《标记免疫分析与临床》
CAS
2023年第2期203-207,共5页
Labeled Immunoassays and Clinical Medicine
基金
航天中心医院科研基金项目(编号:YN201914)。
