摘要
目的:研究bFGF、TGF-β1在体表海绵状静脉畸形中的表达及其意义。方法:体表海绵状静脉畸形标本25例,正常中、小静脉各12例。Envision法免疫组织化学染色观察bFGF、TGF-β1表达,半定量分析。结果:海绵状静脉畸形和正常中、小静脉中bFGF和TGF-β1表达都很微弱,无明显差别。毛细血管和毛细血管后微静脉的血管壁有较强TGF-β1表达,呈棕黄和棕黑色斑块状包绕管腔。结论:bFGF和TGF-β1分泌少可能不是体表海绵状静脉畸形始发原因,但与畸形病理结构形成有一定关系。
Objective: To study the expression of bFGF and TGF-β1 in cavernous venous malformation of body surface. Methods: Envision immunohistochemical stain was used to detect the expression of bFGF and TGF-β1 in 25 cases of cavernous venous malformations, 12 cases of normal medium-sized veins and 12 cases of normal small veins, the results were analyzed semi-quantitatively. Results: Cavernous venous malformations,medium-sized veins and small veins all expressed bFGF and TGF-β1 weakly with no difference,but capillaries and postcapillary venules strongly expressed TGF-β1 with brown,yellow and black stain around the vessels. Conclusion: The weak expression of bFGF and TGF-β1 may not be the initial cause of cavernous venous malformation,but it may be related to the formation of pathologic structure.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2002年第11期1246-1248,共3页
Academic Journal of Second Military Medical University
基金
长海医院"123"人才基金项目(99360967).
