摘要
骨关节炎是人体关节生理性退化的表现,其发病原因复杂,具有难以逆转的特征。一氧化氮是关节产生病理变化的关键标志物之一,在骨关节炎患者的血液、关节滑液中均可检测到该分子及其合酶。近年来中药作为新药开发的重要来源之一,已成为国内治疗骨关节炎的一种核心方法。中药可通过对一氧化氮及其合酶的影响进而起到保护软骨、减轻局部炎症的作用,从而达到预防或缓解骨关节炎的目的。本文概述了骨关节炎中一氧化氮及其合酶的作用,并从中药复方、有效化学成分两个方面综述中药通过干预一氧化氮分子抑制骨关节炎的研究进展,指出了一氧化氮及其合酶与骨关节炎病程中关键信号通路之间的关系,提示中药可以通过靶向一氧化氮治疗骨关节炎的新思路。
Osteoarthritis is a manifestation of physiological degeneration of human joints with complex pathogenesis and irreversible manifestations.Nitric oxide is one of the key markers of pathological changes in joints,and this molecule and its synthase can be detected in the blood and synovial fluid of patients with osteoarthritis.As one of the important sources of new drug development,Chinese medicine has become a central therapy for osteoarthritis in China.In addition,Chinese medicine can prevent or alleviate osteoarthritis by protecting cartilage and reducing local inflammation via interventions in nitric oxide and nitric oxide synthase.This paper provides an overview of nitric oxide/nitric oxide synthase in osteoarthritis and the research progress in inhibiting osteoarthritis by intervening in nitric oxide molecules from the perspective of Chinese medicine compounds and effective chemical composition.The relationship between nitric oxide/nitric oxide synthase and the critical signaling pathways in the process of osteoarthritis was studied,suggesting that Chinese medicine can treat osteoarthritis by targeting nitric oxide.
作者
陈春
黄月英
鲍蕾蕾
卞俊
CHEN Chun;HUANG Yue-ying;BAO Lei-lei;BIAN Jun(Jiangxi University of Chinese Medicine,Nanchang 330004,China;The Third Affiliated Hospital of Naval Medical University,Shanghai 200438,China;The First Affiliated Hospital of Naval Medical University,Shanghai 200433,China)
出处
《解放军药学学报》
CAS
2023年第2期165-171,共7页
Pharmaceutical Journal of Chinese People's Liberation Army
基金
军队卫勤创新专项基金,No.20WQ011。
关键词
中药
一氧化氮
一氧化氮合酶
骨关节炎
Chinese medicine
nitric oxide
nitric oxide synthase
osteoarthritis
