摘要
噬菌体是能特异性感染细菌的病毒,自发现以来一直被用作抗菌药物。但随着抗生素的广泛使用,噬菌体疗法逐渐被淡忘。目前,抗生素耐药性(尤其是多药耐药)的出现,严重威胁着患者的生命和健康,抗生素耐药已成为一个全球性的公共卫生问题,因此寻找新的治疗方法非常必要。在西方国家长期被忽视的噬菌体疗法,如今正重现生机。本文通过查阅国内外大量病例,对噬菌体与抗生素联合治疗的一些实例进行了讨论,阐述了这种双重治疗的可行性,指出其面临的挑战,并且还阐述了噬菌体和抗生素之间可能存在的作用机制。
Phage are viruses that specifically infect bacteria and have been used as antimicrobial agents since discovery.However,with the widespread use of antibiotics,phage therapy gradually faded into oblivion.At present,the emergence of antibiotic resistance(especially multi-drug resistance)seriously endangers the life and health of patients.Therefore,antibiotic resistance has become a global public health problem,which puts forward the necessity of finding new treatment methods.Long neglected in the West,phage therapy is regaining momentum.In this paper,we discussed some examples of phage and antibiotic combinations by examining a relatively large number of cases,at home and abroad,elaborated the feasibility of this dual therapy,and pointed out its challenges.In addition,we illustrated some possible mechanisms of the interaction between phages and antibiotics.
作者
冯璐瑶
朱晓飞
吴仲文
李兰娟
FENG Lu-yao;ZHU Xiao-fei;WU Zhong-wen;LI Lan-juan(State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Centre for Infectious Diseases,Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou,Zhejiang 310000,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
2023年第3期357-360,365,共5页
Chinese Journal of Microecology
基金
国家重点研发计划(2018YFC200050)。
关键词
耐药性
噬菌体
抗生素
联合疗法
Drug resistance
Phage
Antibiotic
Combination therapy
