摘要
脾虚膏脂转输障碍是血脂异常的关键病机。脾失健运引起肝脏代谢功能障碍可能导致血脂异常。肠道功能紊乱是脾虚膏脂转输障碍的启动因素,以其介导“炎症-代谢”紊乱为切入点,深入揭示血脂异常疾病发病机制以提高中西医结合防治水平逐渐成为基础和临床研究焦点和热点。从肠源性高密度脂蛋白(high-density lipoprotein 3,HDL3)调控脂多糖(lipopolysaccharide,LPS)介导Kupffer-肝细胞cross-talk的角度,深入分析脾虚膏脂转输障碍的分子生物学机制,揭示健脾化浊法的效应机制,为临床防治血脂异常提供科学依据。
Spleen deficiency leading to the dysfunction of grease transfer is the key pathogenesis of dyslipidemia. Liver metabolic dysfunction caused by spleen failure may lead to dyslipidemia. Intestinal dysfunction is the initiating factor of spleen deficiency leading to the dysfunction of grease transfer. With its mediation of “inflammation-metabolism” disorder as the starting point, it has gradually become the focus of basic and clinical research to reveal the pathogenesis of dyslipidemia diseases in order to improve the level of prevention and treatment of integrated traditional Chinese and western medicine. In this paper, from the perspective of intestinal HDL3regulation of LPS-mediated Kupffer-hepatocyte cross-talk, the molecular biological mechanism of spleen deficiency leading to the dysfunction of grease transfer is deeply analyzed, and the effect mechanism of the method of invigorating spleen and removing turbidity is revealed, providing the scientific basis for clinical prevention and treatment of dyslipidemia.
作者
翟亚荣
孟嘉伟
张琦
裘雪莹
于宁
王杰
曹慧敏
王群
隋国媛
贾连群
ZHAI Yarong;MENG Jiawei;ZHANG Qi;QIU Xueying;YU Ning;WANG Jie;CAO Huimin;WANG Qun;SUI Guoyuan;JIA Lianqun(TCM-Integrated Hospital of Southern Medical University,Guangzhou,510315,Guangdong,China;Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第2期75-77,共3页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(82074145,81974548,81803860)
沈阳市中青年科技创新人才支持计划项目(RC210094)。
